ArticleNature communications2023
Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The metabolic syndrome-cancer axis: global research trends and clinical landscapes.Frontiers in endocrinology · 2026Pooled it
- Trial
- Metabolic syndrome severity and the effects of intensive blood pressure lowering: Results from the STEP randomized trial.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Continuous metabolic syndrome score and cardiometabolic multimorbidity risk in three nationwide cohorts.Scientific reports · 2026Article
- Association between continuous metabolic syndrome score and incident dementia: a longitudinal study of middle-aged and older Chinese adults.BMC neurology · 2026Article
- Hepatic Steatosis Severity Prediction in Nonobese Individuals: Machine Learning Model Development and Validation.Journal of medical Internet research · 2026Article
- Joint assessment of frailty index and metabolic syndrome score for cardiovascular disease in middle aged and older Chinese adults: insights from a national cohort study 2011-2020.BMC cardiovascular disorders · 2026Article
- Association of cumulative exposure and dynamic change patterns of metabolic syndrome score with cardiometabolic multimorbidity progression among middle-aged and older Chinese adults: a longitudinal analysis based on CHARLS.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Article
- Sex differences in prevalence and clinical correlates for psychotic symptoms in first-episode drug-naïve patients with bipolar disorder: a cross-sectional study.Annals of general psychiatry · 2026Article
- Machine learning ensemble meets clinical practice: developing a real-world risk prediction model for metabolic syndrome using super learner and scorecard approaches.Journal of advanced research · 2026Article
- Dietary patterns in Xinjiang, Western China and associations with metabolic syndrome: a population-based study.Public health nutrition · 2026Article
- Association between uric acid to high-density cholesterol ratio (UHR) and in-stent neoatherosclerosis: an optical coherence tomography study.BMC cardiovascular disorders · 2026Article
- Utility of the US Metabolic Syndrome Severity Calculator for Group-Level Comparison in Estonia.Medicina (Kaunas, Lithuania) · 2026Article
- Metabolic syndrome severity and all-cause mortality in the CLHLS biomarker subsample of older Chinese adults.Frontiers in public health · 2026Article
- Association between occupational sedentary behavior and metabolic syndrome and related diseases in males: A cross-sectional study.PloS one · 2026Article
- Quantifying Metabolic Syndrome Severity: Methodological Evolution, Clinical Validation, and Translational Perspectives.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Association of hyperuricemia and a three-component lifestyle score with elevated cardiometabolic risk: a health-examination-based cross-sectional study.Frontiers in endocrinology · 2026Article
- The Predictive Ability and Trend of Continuous Metabolic Syndrome (cMets) Score as a Marker for the Presence of Metabolic Syndrome among Iranian Adults from 2007 to 2025 Using STEPS Studies.International journal of preventive medicine · 2026Article
- A cohort study in Southern Xinjiang, China, 2018-2023 on the association of metabolic syndrome components and their interactions with cardiovascular disease risk.Frontiers in cardiovascular medicine · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic syndrome (MetS) is characterized by metabolic dysfunctions and could predict future risk for cardiovascular diseases (CVDs). However, the traditionally defined dichotomous MetS neither reflected MetS severity nor considered demographic variations. Here we develop a continuous, age-sex-ethnicity-specific MetS score based on continuous measures of the five metabolic dysfunctions (waist circumference [WC], triglycerides [TG], high-density lipoprotein cholesterol [HDL-C], mean arterial pressure [MAP], and fasting blood glucose [FBG]). We find that the weights of metabolic dysfunctions in the score vary across age-sex-ethnicity-specific subgroups, with higher weights for TG, HDL-C, and WC. Each unit increase in the score is associated with increased risks for hyperlipidemia, diabetes, and hypertension, and elevated levels of HbA1c, cholesterol, body mass index, and serum uric acid. The score shows high sensitivity and accuracy for detecting CVD-related risk factors and is validated in different geographical regions. Our study would advance early identification of CVD risks and, more broadly, preventive medicine and sustainable development goals.
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