ArticleNature communications2023
A carbon-nitrogen negative feedback loop underlies the repeated evolution of cnidarian-Symbiodiniaceae symbioses.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 34 citations in OpenAlex.
- Heterotrophy and symbiosis affect energy reserves for pedal lacerates in the sea anemonePeerJ · 2026Article
- A quick and reliable menthol-induced bleaching protocol for the Caribbean staghorn coral,PeerJ · 2026Article
- The temperate coralRoyal Society open science · 2025Article
- Hypoxia disrupts metabolism in coral and sea anemone larvae.The Journal of experimental biology · 2025Article
- Inhibition of protein or glutamine biosynthesis affect the light-induced dephosphorylation of the SBiP1 chaperone in Symbiodiniaceae.Bioscience reports · 2025Article
- Stability of the cnidarian-dinoflagellate symbiosis is primarily determined by symbiont cell-cycle arrest.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Resolving Acuticulata (Metridioidea: Enthemonae: Actiniaria), a clade containing many invasive species of sea anemones.PloS one · 2025Article
- Elaborating the molecular characteristics of corals' different tolerance to environmental stress in Sanya Luhuitou based on multi-omics analysis.Frontiers in microbiology · 2025Article
- Symbiodiniaceae algal symbionts of Pocillopora damicornis larvae provide more carbon to their coral host under elevated levels of acidification and temperature.Communications biology · 2024Article
- Using clusterProfiler to characterize multiomics data.Nature protocols · 2024Review
- Coral larvae increase nitrogen assimilation to stabilize algal symbiosis and combat bleaching under increased temperature.PLoS biology · 2024Article
- Youthful insight: Nitrogen sequestration in larvae provides clues to coral bleaching.PLoS biology · 2024Article
- Article
- Enhanced metabolic entanglement emerges during the evolution of an interkingdom microbial community.Nature communications · 2024Article
- Unlocking the genomic potential of Red Sea coral probiotics.Scientific reports · 2024Article
- Gene expression of Pocillopora damicornis coral larvae in response to acidification and ocean warming.BMC genomic data · 2024Article
- Coupled carbon and nitrogen cycling regulates the cnidarian-algal symbiosis.Nature communications · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Symbiotic associations with Symbiodiniaceae have evolved independently across a diverse range of cnidarian taxa including reef-building corals, sea anemones, and jellyfish, yet the molecular mechanisms underlying their regulation and repeated evolution are still elusive. Here, we show that despite their independent evolution, cnidarian hosts use the same carbon-nitrogen negative feedback loop to control symbiont proliferation. Symbiont-derived photosynthates are used to assimilate nitrogenous waste via glutamine synthetase-glutamate synthase-mediated amino acid biosynthesis in a carbon-dependent manner, which regulates the availability of nitrogen to the symbionts. Using nutrient supplementation experiments, we show that the provision of additional carbohydrates significantly reduces symbiont density while ammonium promotes symbiont proliferation. High-resolution metabolic analysis confirmed that all hosts co-incorporated glucose-derived
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