ArticleNature communications2023
Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting.Nature genetics · 2026Pooled it
- Type IIB PKA serves as the primary effector of Gs-coupled receptor-potentiated insulin secretion in mice by orchestrating ion channels and granule phenotype.Diabetologia · 2026Article
- Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation.Cell proliferation · 2026Article
- Association Between Serum Follicle-Stimulating Hormone Levels and Risk of Diabetes in Middle-Aged Men: A Long-Term Population-Based Longitudinal Study.Endocrinology, diabetes & metabolism · 2026Article
- Advances in the Study of Endometrial Receptivity and Glucose Metabolism Mechanisms in Insulin Resistance.Endocrinology, diabetes & metabolism · 2026Review
- The BDNF/TrkB/CREB signaling improves chronic stress-induced decreased ovarian reserve by inhibiting pyroptosis of granulosa cells and disorders of sex hormone secretion.Journal of ovarian research · 2026Article
- Follicle-Stimulating Hormone and Its Emerging Role in Coronary Atherosclerosis Among Postmenopausal Women: A Comprehensive Review.International journal of women's health · 2026Review
- Mechanistic redundancy and hierarchy of aging mechanisms: implications for strategies to extend healthspan and biomarker integration.Frontiers in aging · 2026Review
- Central SELENOT deficiency impairs gonadotrope axis function, sexual behavior, and fertility in male and female mice.JCI insight · 2025Article
- Targeting FSH for osteoporosis, obesity, and Alzheimer's disease.Trends in molecular medicine · 2025Review
- Unraveling the Role of MDK-SDC4 Interaction in Pancreatic Cancer-Associated New-Onset Diabetes by Single-Cell Transcriptomic Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- ChemPerturb-seq screen identifies a small molecule cocktail enhancing human beta cell survival after subcutaneous transplantation.Cell stem cell · 2025Article
- Targeting FSHR is a highly promising strategy for improving cognitive impairment in postmenopausal women.Molecular psychiatry · 2025Article
- Impact of Heat Stress on Gene Expression in the Hypothalamic-Pituitary-Ovarian Axis of Hu Sheep.Animals : an open access journal from MDPI · 2025Article
- Maternal obesity promotes impaired renal autophagic process and kidney injury in male offspring.International journal of obesity (2005) · 2025Article
- A systematic review and meta-analysis of follicle-stimulating hormone levels among men with type 2 diabetes.Basic and clinical andrology · 2025Review
- Article
- Longitudinal trajectories of cognitive decline and temporal lobe atrophy based on baseline gonadotropins and testosterone.Frontiers in neuroscience · 2025Article
- Article
- Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity.Research square · 2024Article
Corrections and comments
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Authors and funding
24 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Follicle-stimulating hormone (FSH) is involved in mammalian reproduction via binding to FSH receptor (FSHR). However, several studies have found that FSH and FSHR play important roles in extragonadal tissue. Here, we identified the expression of FSHR in human and mouse pancreatic islet β-cells. Blocking FSH signaling by Fshr knock-out led to impaired glucose tolerance owing to decreased insulin secretion, while high FSH levels caused insufficient insulin secretion as well. In vitro, we found that FSH orchestrated glucose-stimulated insulin secretion (GSIS) in a bell curve manner. Mechanistically, FSH primarily activates Gαs via FSHR, promoting the cAMP/protein kinase A (PKA) and calcium pathways to stimulate GSIS, whereas high FSH levels could activate Gαi to inhibit the cAMP/PKA pathway and the amplified effect on GSIS. Our results reveal the role of FSH in regulating pancreatic islet insulin secretion and provide avenues for future clinical investigation and therapeutic strategies for postmenopausal diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.