ArticleBritish journal of anaesthesia2024
Evaluation of putative signatures of consciousness using specific definitions of responsiveness, connectedness, and consciousness.
Article in British journal of anaesthesia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03284307 (UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study), which is not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study
Who cites it
13 citing papers in PubMed.
- Conserved neural dynamics of anesthesia and the oblivion of species.Nature neuroscience · 2026Article
- Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization.Cells · 2026Review
- Ketamine Across the Dose-State Continuum: EEG Signatures, Network Dynamics, and Implications for Brain-State Monitoring in Anesthesia and Critical Care.Brain sciences · 2026Review
- Dreaming during anaesthesia: a scoping review.British journal of anaesthesia · 2026Article
- A three-component dynamical index of consciousness-related neural organisation.Biological cybernetics · 2026Article
- An experimental study of the effect of neuromuscular blockade on EEG-based measures of awareness.Scientific reports · 2026Article
- Esketamine Preserves Network Connectivity and Promotes Recovery in Consciousness Disorders.CNS neuroscience & therapeutics · 2026Article
- Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans.PLoS biology · 2025Article
- Cortical connectivity, local dynamics and stability correlates of global conscious states.Communications biology · 2025Article
- The role of etiology in the identification of clinical markers of consciousness: comparing EEG alpha power, complexity, and spectral exponent.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- The relationship of bispectral index values to conscious state: an analysis of two volunteer cohort studies.British journal of anaesthesia · 2025Article
- Consciousness and the Dying Brain.Anesthesiology · 2024Review
- Anesthesia and the neurobiology of consciousness.Neuron · 2024Review
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13 authors.
Funding
Abstract
backgroundUnderstanding the neural correlates of consciousness has important ramifications for the theoretical understanding of consciousness and for clinical anaesthesia. A major limitation of prior studies is the use of responsiveness as an index of consciousness. We identified a collection of measures derived from unresponsive subjects and more specifically their association with consciousness (any subjective experience) or connectedness (specific experience of environmental stimuli).
methodsUsing published data generated through the UNderstanding Consciousness Connectedness and Intra-Operative Unresponsiveness Study (NCT03284307), we evaluated 10 previously published resting-state EEG-based measures that were derived using unresponsiveness as a proxy for unconsciousness. Measures were tested across dexmedetomidine and propofol sedation and natural sleep. These markers represent the complexity, connectivity, cross-frequency coupling, graph theory, and power spectrum measures.
resultsAlthough many of the proposed markers were associated with consciousness per se (reported subjective experience), none were specific to consciousness alone; rather, each was also associated with connectedness (i.e. awareness of the environment). In addition, multiple markers showed no association with consciousness and were associated only with connectedness. Of the markers tested, loss of normalised-symbolic transfer entropy (front to back) was associated with connectedness across all three experimental conditions, whereas the transition from disconnected consciousness to unconsciousness was associated with significant decreases in permutation entropy and spectral exponent (P<0.05 for all conditions).
conclusionsNone of the proposed EEG-based neural correlates of unresponsiveness corresponded solely to consciousness, highlighting the need for a more conservative use of the term (un)consciousness when assessing unresponsive participants. CLINICAL
trial registrationNCT03284307.
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