Evidence map›Paper›PMID 37914398›Full record

ArticleRNA (New York, N.Y.)2023

Identification of a putative Gag binding site critical for feline immunodeficiency virus genomic RNA packaging.

Anjana Krishnan, Lizna M Ali, Suresha G Prabhu, Vineeta N Pillai, Akhil Chameettachal, Valérie Vivet-Boudou, Serena Bernacchi, Farah Mustafa, Roland Marquet, Tahir A Rizvi

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Anjana KrishnanDepartment of Microbiology and Immunology, College of Medicine and Health Sciences (CMHS), United Arab Emirates University (UAEU), Al Ain, United Arab Emirates.
Lizna M AliDepartment of Microbiology and Immunology, College of Medicine and Health Sciences (CMHS), United Arab Emirates University (UAEU), Al Ain, United Arab Emirates.
Suresha G PrabhuDepartment of Microbiology and Immunology, College of Medicine and Health Sciences (CMHS), United Arab Emirates University (UAEU), Al Ain, United Arab Emirates.
Vineeta N PillaiDepartment of Microbiology and Immunology, College of Medicine and Health Sciences (CMHS), United Arab Emirates University (UAEU), Al Ain, United Arab Emirates.
Akhil ChameettachalDepartment of Microbiology and Immunology, College of Medicine and Health Sciences (CMHS), United Arab Emirates University (UAEU), Al Ain, United Arab Emirates.
Valérie Vivet-BoudouUniversité de Strasbourg, CNRS, Architecture et Réactivité de l'ARN, UPR 9002, 67084 Strasbourg cedex, France.
Serena BernacchiUniversité de Strasbourg, CNRS, Architecture et Réactivité de l'ARN, UPR 9002, 67084 Strasbourg cedex, France.
Farah MustafaDepartment of Biochemistry, College of Medicine and Health Sciences (CMHS), United Arab Emirates University (UAEU), Al Ain, United Arab Emirates.
Roland MarquetUniversité de Strasbourg, CNRS, Architecture et Réactivité de l'ARN, UPR 9002, 67084 Strasbourg cedex, France tarizvi@uaeu.ac.ae r.marquet@ibmc-cnrs.unistra.fr.
Tahir A RizviDepartment of Microbiology and Immunology, College of Medicine and Health Sciences (CMHS), United Arab Emirates University (UAEU), Al Ain, United Arab Emirates tarizvi@uaeu.ac.ae r.marquet@ibmc-cnrs.unistra.fr.
United Arab Emirates University · AECentre National de la Recherche Scientifique · FR

Funding

Abu Dhabi (ASPIREMRIAD) VRI-20-10Abu Dhabi Department of Education and Knowledge (ADEK) ASPIRE AARE20-344Abu Dhabi Department of Education and Knowledge (ADEK) ASPIRE AARE20-344/21M150College of Medicine and Health Sciences, United Arab Emirates University NP-22-33/12M131UAE University UPAR 12M103Zayed Bin Sultan Center for Health Sciences grant UCBR 31R143
6 · The paper itself

Abstract

The retroviral Gag precursor plays a central role in the selection and packaging of viral genomic RNA (gRNA) by binding to virus-specific packaging signal(s) (psi or ψ). Previously, we mapped the feline immunodeficiency virus (FIV) ψ to two discontinuous regions within the 5' end of the gRNA that assumes a higher order structure harboring several structural motifs. To better define the region and structural elements important for gRNA packaging, we methodically investigated these FIV ψ sequences using genetic, biochemical, and structure-function relationship approaches. Our mutational analysis revealed that the unpaired U

Indexed as

Immunodeficiency Virus, FelineAnimalsBinding SitesCatsGenomicsHumansRNA, Guide, CRISPR-Cas SystemsRNA, ViralVirus AssemblyRNA, Guide, CRISPR-Cas SystemsRNA, Viralfeline immunodeficiency virusfilter-binding assaysGag/RNA interactionshSHAPEretrovirusesRNA packaging signal (ψ)RNA secondary structure

Identifiers

PMID37914398
PMCPMC10726167
OpenAlexW4388126290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.