Observational studyJournal of neurointerventional surgery2024
CLinical EValuation of WEB 17 device in intracranial aneuRysms (CLEVER): procedural, 30-day and 1-year safety results for ruptured and unruptured aneurysms.
Observational study in Journal of neurointerventional surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03844334 (CLEVER), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CLEVER: CLinical EValuation of WEB 0.017 Device in Intracranial AneuRysms
Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Long-Term Follow-up of the Woven EndoBridge (WEB) Device for the Treatment of Broad Based Intracranial Aneurysms: A Single-Center Retrospective Observational Analysis.Clinical neuroradiology · 2026Observational
- Widening the treatment of shallow intracranial aneurysms with intrasaccular flow disruption: The flat WEB experience.The neuroradiology journal · 2026Article
- Ruptured aneurysm of the middle cerebral artery with cerebral herniation treated with Woven EndoBridge via distal radial artery access: a case report.Journal of medical case reports · 2026Article
- New Artisse intrasaccular device for intracranial aneurysm treatment: short term clinical and angiographic result from the prospective registry INSPIRE-A.Journal of neurointerventional surgery · 2026Article
- Endovascular Treatment of a Bihemispheric Distal Anterior Cerebral Artery A4 Broad-Necked Bifurcation Aneurysm Using the Woven EndoBridge Device: A Case Report.Journal of neuroendovascular therapy · 2026Article
- Endovascular Treatment of Ruptured and Unruptured Wide-Neck Intracranial Aneurysms Using LVIS EVO Stent-Assisted Coiling: Mid-Term Results.Journal of clinical medicine · 2025Article
- Feasibility, safety and efficacy of Woven EndoBridge embolization of intracranial aneurysms with the 2 mm height variants.Neuroradiology · 2025Article
- 15 years of WEB embolization: a transformative journey in aneurysm treatment.Journal of neurointerventional surgery · 2025Article
- Neck apposition is a key factor for aneurysm occlusion after Woven EndoBridge device embolization.Journal of neurointerventional surgery · 2025Article
- CLinical EValuation of WEB 17 device in intracranial aneuRysms (CLEVER): 1-year effectiveness results for ruptured and unruptured aneurysms.Journal of neurointerventional surgery · 2025Observational
- The impact of pre-treatment aneurysm angulation. What happens with WEB devices at follow-up?Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Propensity Score-matched Comparison of WEB 17 and WEB 21 with 4-7 mm Device Sizes for the Treatment of Unruptured Intracranial Aneurysms.Clinical neuroradiology · 2024Article
- Intrasaccular Treatment of Intracranial Aneurysms: A Comprehensive Review.Journal of clinical medicine · 2024Review
- Current state of endovascular treatment of anterior cerebral artery aneurysms.Frontiers in neurology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 19 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntrasaccular flow disruption is an endovascular approach for the treatment of wide-neck aneurysms and, more specifically, wide-neck bifurcation aneurysms, which are challenging to treat with previously developed technologies. The Woven EndoBridge (WEB) device has demonstrated its efficacy and safety, for both unruptured and ruptured aneurysms.
methodsThe CLEVER study was an observational, multicenter, prospective study conducted in 17 European investigational sites using the WEB 17 device, for the treatment of ruptured and unruptured aneurysms. The study objective was to provide safety and efficacy data on the WEB 17 device in the treatment of wide-neck bifurcation aneurysms. Imaging results were assessed independently by a Corelab and adverse events adjudicated by a Clinical Event Adjudicator. This analysis reports procedural results and safety at 30 days and 12 months.
resultsA total of 163 patients (mean age 58.1 years; 68.1% women) with 103 unruptured aneurysms and 60 ruptured aneurysms were enrolled. Most aneurysms were located on the anterior communicating artery (ACom) (37.4%) or the middle cerebral artery (MCA) bifurcation (30.1%). Aneurysm widths ranged from 2.0-9.2 mm, and the mean sac width was 5.0 mm. The WEB procedure was successfully completed in 163 patients (100%). At the 12-month follow-up, major stroke events occurred in 3 of 163 patients (1.8%), and no device-related mortality was observed.
conclusionEndovascular treatment of ruptured and unruptured wide-neck bifurcation aneurysms using WEB 17 is safe, with a low complication rate and no device-related mortality. In particular, none of the ruptured aneurysms bled again up to 1 year of follow-up. TRIAL REGISTRATION NUMBER: NCT03844334.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.