Evidence map›Paper›PMID 37914222›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Connectivity patterns of the core resting-state networks associated with apathy in late-life depression.

Jean-Charles Roy, Thomas Desmidt, Sébastien Dam, Iris Mirea-Grivel, Louise Weyl, Elise Bannier, Laurent Barantin, Dominique Drapier, Jean-Marie Batail, Renaud David and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jean-Charles RoyFrom the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David) jc.roy@ch-guillaumeregnier.fr.
Thomas DesmidtFrom the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David).
Sébastien DamFrom the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David).
Iris Mirea-GrivelFrom the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David).
Louise WeylFrom the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David).
Elise BannierFrom the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David).
Laurent BarantinFrom the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David).
Dominique DrapierFrom the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David).
Jean-Marie BatailFrom the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David).
Renaud DavidFrom the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David).
Julie Coloigner *From the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David).
Gabriel H Robert *From the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David).
Université de Tours · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApathy is associated with reduced antidepressant response and dementia in late-life depression (LLD). However, the functional cerebral basis of apathy is understudied in LLD. We investigated the functional connectivity of 5 resting-state networks (RSN) hypothesized to underlie apathy in LLD.

methodsResting-state functional MRI data were collected from individuals with LLD who did not have dementia as well as healthy older adults between October 2019 and April 2022. Apathy was evaluated using the diagnostic criteria for apathy (DCA), the Apathy Evaluation Scale (AES) and the Apathy Motivation Index (AMI). Subnetworks whose connectivity was significantly associated with each apathy measure were identified via the threshold-free network-based statistics. Regions that were consistently associated with apathy across the measures were reported as robust findings.

resultsOur sample included 39 individuals with LLD who did not have dementia and 26 healthy older adults. Compared with healthy controls, individuals with LLD had an altered intra-RSN and inter-RNS connectivity in the default mode, the cingulo-opercular and the frontoparietal networks. All 3 apathy measurements showed associations with modified intra-RSN connectivity in these networks, except for the DCA in the cingulo-opercular network. The AMI scores showed stronger associations with the cingulo-opercular and frontoparietal networks, whereas the AES had stronger associations with the default mode network and the goal-oriented behaviour network. LIMITATIONS: The study was limited by the small number of participants without apathy according to the DCA, which may have reduced the statistical power of between-group comparisons. Additionally, the reliance on specific apathy measures may have influenced the observed overlap in brain regions.

conclusionOur findings indicate that apathy in LLD is consistently associated with changes in both intra-RSN and inter-RSN connectivity of brain regions implicated in goal-oriented behaviours. These results corroborate previous findings of altered functional RSN connectivity in severe LLD.

Indexed as

ApathyDementiaAgedBrainDepressionHumansMagnetic Resonance Imaging

Identifiers

PMID37914222
PMCPMC10620011
OpenAlexW4388129320

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.