Evidence map›Paper›PMID 37914183›Full record

ReviewBMJ global health2023

Research priorities for the secondary prevention and management of acute rheumatic fever and rheumatic heart disease: a National Heart, Lung, and Blood Institute workshop report.

Ganesan Karthikeyan, David Watkins, Gene Bukhman, Madeleine W Cunningham, John Haller, Mary Masterson, George A Mensah, Ana Mocumbi, Babu Muhamed, Emmy Okello and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in BMJ global health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Valve biology and rheumatic heart disease pathogenesis.Nature cardiovascular research · 2026
    Review
  3. Acute rheumatic fever and rheumatic heart disease.Nature reviews. Disease primers · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 7 countries.

Ganesan Karthikeyan *All India Institute of Medical Sciences, New Delhi, India.
David Watkins *Division of General Internal Medicine, University of Washington, Seattle, Washington, USA davidaw@uw.edu.ORCID 0000-0001-6341-9595
Gene BukhmanDivision of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Madeleine W CunninghamThe University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
John HallerNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Mary MastersonNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.ORCID 0000-0002-3369-9183
George A MensahNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Ana MocumbiNon-Communicable Diseases Division, Instituto Nacional de Saúde, Marracuene, Mozambique.ORCID 0000-0002-9564-2860
Babu MuhamedThe University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Emmy OkelloCardiology, Uganda Heart Institute Ltd, Kampala, Uganda.
Nona SotoodehniaCardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-2705-6237
Tafadzwa MachipisaCape Heart Institute (CHI), Department of Medicine, University of Cape Town, Rondebosch, South Africa.ORCID 0000-0002-4882-9067
Anna RalphMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.ORCID 0000-0002-2253-5749
Rosemary WyberEND RHD Program, Telethon Kids Institute, Perth, Western Australia, Australia.ORCID 0000-0003-3904-9269
Andrea BeatonPediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
National Heart Lung and Blood Institute · USUniversity of Washington · USAll India Institute of Medical Sciences · INAustralian Institute of Aboriginal and Torres Strait Islander Studies · AUBrigham and Women's Hospital · USCharles Darwin University · AUCincinnati Children's Hospital Medical Center · USEduardo Mondlane University · MZUganda Management Institute · UGUniversity of Cape Town · ZAUniversity of Oklahoma Health Sciences Center · USUniversity of Tennessee Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secondary prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) involves continuous antimicrobial prophylaxis among affected individuals and is recognised as a cornerstone of public health programmes that address these conditions. However, several important scientific issues around the secondary prevention paradigm remain unresolved. This report details research priorities for secondary prevention that were developed as part of a workshop convened by the US National Heart, Lung, and Blood Institute in November 2021. These span basic, translational, clinical and population science research disciplines and are built on four pillars. First, we need a better understanding of RHD epidemiology to guide programmes, policies, and clinical and public health practice. Second, we need better strategies to find and diagnose people affected by ARF and RHD. Third, we urgently need better tools to manage acute RF and slow the progression of RHD. Fourth, new and existing technologies for these conditions need to be better integrated into healthcare systems. We intend for this document to be a reference point for research organisations and research sponsors interested in contributing to the growing scientific community focused on RHD prevention and control.

Indexed as

Rheumatic FeverRheumatic Heart DiseaseHumansNational Heart, Lung, and Blood Institute (U.S.)Research DesignSecondary PreventionUnited StatesCardiovascular diseasePrevention strategiesPublic HealthReviewTreatment

Identifiers

PMID37914183
PMCPMC10618973
OpenAlexW4388142602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.