Evidence map›Paper›PMID 37913975›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2024

Differential gene expression and developmental pathologies associated with persistent organic pollutants in sentinel fish in Troutman Lake, Sivuqaq, Alaska.

Renee Jordan-Ward, Frank A von Hippel, Catherine A Wilson, Zyled Rodriguez Maldonado, Danielle Dillon, Elise Contreras, Alison Gardell, Michael R Minicozzi, Tom Titus, Bobby Ungwiluk and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Renee Jordan-WardDepartment of Biological Sciences, Northern Arizona University, 617 S. Beaver St., Flagstaff, AZ 86011, USA.
Frank A von HippelDepartment of Community, Environment and Policy, Mel & Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., P.O. Box 245210, Tucson, AZ 85724, USA. Electronic address: frankvonhippel@arizona.edu.
Catherine A WilsonInstitute of Neuroscience, University of Oregon, 1254 University of Oregon, Eugene, OR 97403, USA.
Zyled Rodriguez MaldonadoDepartment of Biological Sciences, Northern Arizona University, 617 S. Beaver St., Flagstaff, AZ 86011, USA.
Danielle DillonDepartment of Biological Sciences, Northern Arizona University, 617 S. Beaver St., Flagstaff, AZ 86011, USA.
Elise ContrerasDepartment of Biological Sciences, Northern Arizona University, 617 S. Beaver St., Flagstaff, AZ 86011, USA.
Alison GardellSchool of Interdisciplinary Arts and Sciences, University of Washington Tacoma, 1900 Commerce Street, Tacoma, WA 98402, USA.
Michael R MinicozziDepartment of Biological Sciences, Minnesota State University Mankato, 242 Trafton Science Center South, Mankato, MN, 56001, USA.
Tom TitusInstitute of Neuroscience, University of Oregon, 1254 University of Oregon, Eugene, OR 97403, USA.
Bobby UngwilukAlaska Community Action on Toxics, 1225 E. International Airport Road, Suite 220, Anchorage, AK 99518, USA.
Pamela MillerAlaska Community Action on Toxics, 1225 E. International Airport Road, Suite 220, Anchorage, AK 99518, USA.
David CarpenterInstitute for Health and the Environment, University at Albany, 5 University Place, Rensselaer, NY 12144, USA.
John H PostlethwaitInstitute of Neuroscience, University of Oregon, 1254 University of Oregon, Eugene, OR 97403, USA.
Samuel ByrneMiddlebury College, Department of Biology and Global Health Program, 14 Old Chapel Rd, Middlebury, VT 05753, USA.
C Loren BuckDepartment of Biological Sciences, Northern Arizona University, 617 S. Beaver St., Flagstaff, AZ 86011, USA.
Northern Arizona University · USUniversity of Oregon · USMiddlebury College · USMinnesota State University, Mankato · USUniversity at Albany, State University of New York · USUniversity of Arizona · USUniversity of Washington Tacoma · US

Funding

Resources for Teleost Gene Duplicates and Human DiseaseR01OD011116 · OD · UNIVERSITY OF OREGON · PI POSTLETHWAIT, JOHN H. · 2012 to 2020
$5.4M
Protecting the Health of Future Generations: Assessing and Preventing Exposures to Endocrine-Disrupting Flame Retardant Chemicals & PCBs in Two Alaska Native Arctic Communities on St. Lawrence IslandR01ES019620 · NIEHS · ALASKA COMMUNITY ACTION ON TOXICS (ACAT) · PI BUCK, CHARLES LOREN, CARPENTER, DAVID ORLO · 2011 to 2021
$5.3M
Restoring Northeast Cape for the Health and Well-Being of the Yupik Communities of St. Lawrence Island, AlaskaR01ES032392 · NIEHS · UNIVERSITY OF ARIZONA · PI BUCK, CHARLES LOREN, BYRNE, SAMUEL · 2021 to 2025
$2.9M
NIEHS NIH HHS R01 ES019620NIEHS NIH HHS R01 ES032392NIH HHS R01 OD011116
6 · The paper itself

Abstract

Persistent organic pollutants (POPs) are lipophilic compounds that bioaccumulate in animals and biomagnify within food webs. Many POPs are endocrine disrupting compounds that impact vertebrate development. POPs accumulate in the Arctic via global distillation and thereby impact high trophic level vertebrates as well as people who live a subsistence lifestyle. The Arctic also contains thousands of point sources of pollution, such as formerly used defense (FUD) sites. Sivuqaq (St. Lawrence Island), Alaska was used by the U.S. military during the Cold War and FUD sites on the island remain point sources of POP contamination. We examined the effects of POP exposure on ninespine stickleback (Pungitius pungitius) collected from Troutman Lake in the village of Gambell as a model for human exposure and disease. During the Cold War, Troutman Lake was used as a dump site by the U.S. military. We found that PCB concentrations in stickleback exceeded the U.S. Environmental Protection Agency's guideline for unlimited consumption despite these fish being low trophic level organisms. We examined effects at three levels of biological organization: gene expression, endocrinology, and histomorphology. We found that ninespine stickleback from Troutman Lake exhibited suppressed gonadal development compared to threespine stickleback (Gasterosteus aculeatus) studied elsewhere. Troutman Lake stickleback also displayed two distinct hepatic phenotypes, one with lipid accumulation and one with glycogen-type vacuolation. We compared the transcriptomic profiles of these liver phenotypes using RNA sequencing and found significant upregulation of genes involved in ribosomal and metabolic pathways in the lipid accumulation group. Additionally, stickleback displaying liver lipid accumulation had significantly fewer thyroid follicles than the vacuolated phenotype. Our study and previous work highlight health concerns for people and wildlife due to pollution hotspots in the Arctic, and the need for health-protective remediation.

Indexed as

Environmental PollutantsSmegmamorphaAlaskaAnimalsFishesGene ExpressionHumansLakesLipidsPersistent Organic PollutantsEnvironmental PollutantsLipidsPersistent Organic PollutantsArcticEndocrine-disrupting compoundsFUD siteHistologyMilitary contaminationRNA sequencing

Identifiers

PMID37913975
PMCPMC11793931
OpenAlexW4388024270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.