Evidence map›Paper›PMID 37910781›Full record

Trial reportTherapeutic hypothermia and temperature management2024

Soluble Urokinase-Type Plasminogen Activator Receptor in Comatose Survivors After Out-of-Hospital Cardiac Arrest Treated with Targeted Temperature Management.

John Bro-Jeppesen, Anders M Grejs, Ove Andersen, Anni N Jeppesen, Christophe Duez, Hans Kirkegaard

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Therapeutic hypothermia and temperature management, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

John Bro-JeppesenDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-7187-5734
Anders M GrejsDepartment of Intensive Care Medicine, Aarhus University Hospital, Aarhus, Denmark.
Ove AndersenDepartment of Clinical Research and Emergency, Amager and Hvidovre Hospital, Hvidovre, Denmark.
Anni N JeppesenDepartment of Cardiothoracic and Vascular Surgery, Anaesthesia Section, Aarhus University Hospital, Aarhus, Denmark.
Christophe DuezDepartment of Otolaryngology, Goedstrup Hospital, Central Denmark Region, Glostrup, Denmark.
Hans KirkegaardDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Aarhus University · DKAarhus University Hospital · DKGlostrup Hospital · DKHvidovre Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to whole-body ischemia/reperfusion after out-of-hospital cardiac arrest (OHCA) triggers a systemic inflammatory response where soluble urokinase plasminogen activator receptor (suPAR) is released. This study investigated serial levels of suPAR in differentiated target temperature management and the associations with mortality and 6-month neurological outcome. This is a single-center substudy of the randomized Targeted Temperature Management (TTM) for 24-hour versus 48-hour trial. In this analysis, we included 82 patients and measured serial levels of suPAR at 24, 48, and 72 hours after achievement of target temperature (32-34°C). We assessed all-cause mortality and neurological function evaluated by the Cerebral Performance Categories (CPC) at 6 months after OHCA. Levels of suPAR between TTH groups were evaluated in repeated measures mixed models. Mortality was assessed by the Kaplan-Meier method and serial measurements of suPAR (log

Indexed as

ComaHypothermia, InducedOut-of-Hospital Cardiac ArrestReceptors, Urokinase Plasminogen ActivatorAgedBiomarkersFemaleHumansMaleMiddle AgedTime FactorsTreatment OutcomeBiomarkersPLAUR protein, humanReceptors, Urokinase Plasminogen Activatorcardiac arrestinflammationoutcomepostcardiac arrest syndrometargeted temperature management

Identifiers

PMID37910781
PMCPMC11665269
OpenAlexW4388125462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.