ArticleScience advances2023
A telencephalon cell type atlas for goldfish reveals diversity in the evolution of spatial structure and cell types.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 25 citations in OpenAlex.
- Brain injury reactivates a developmental program driving genesis and integration of transient LGE-class interneurons.Stem cell reports · 2026Article
- Sensory maps in the telencephalic pallium of goldfish.Brain structure & function · 2026Article
- Evolutionarily informed gene sets reveal conserved and lineage-modified transcriptional programs during vertebrate forebrain evolution.bioRxiv : the preprint server for biology · 2026Article
- scGeneBank: cross-species screening of functional gene sets at single-cell resolution.Nucleic acids research · 2026Article
- Dopaminergic Neurons in the Zebrafish Subpallium Belong to the Extended Medial Amygdala.The Journal of comparative neurology · 2025Article
- Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice.Acta neuropathologica · 2025Article
- Early-life growth and cellular heterogeneity in the short-lived African turquoise killifish telencephalon.Biology open · 2025Article
- The neural substrate of navigation using hydrostatic cues in goldfish.Royal Society open science · 2025Article
- Tumor draining lymph nodes connected to cold triple-negative breast cancers are characterized by Th2-associated microenvironment.Nature communications · 2024Article
- Single-Cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Spatially resolved cell atlas of the teleost telencephalon and deep homology of the vertebrate forebrain.Communications biology · 2024Article
- Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses.Nature communications · 2024Article
- Mapping spatial memory in teleosts: a new Frontier in neural logging techniques.Frontiers in physiology · 2024Review
- Medulla oblongata and NCCs are central defenders againstFrontiers in immunology · 2024Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Teleost fish form the largest group of vertebrates and show a tremendous variety of adaptive behaviors, making them critically important for the study of brain evolution and cognition. The neural basis mediating these behaviors remains elusive. We performed a systematic comparative survey of the goldfish telencephalon. We mapped cell types using single-cell RNA sequencing and spatial transcriptomics, resulting in de novo molecular neuroanatomy parcellation. Glial cells were highly conserved across 450 million years of evolution separating mouse and goldfish, while neurons showed diversity and modularity in gene expression. Specifically, somatostatin interneurons, famously interspersed in the mammalian isocortex for local inhibitory input, were curiously aggregated in a single goldfish telencephalon nucleus but molecularly conserved. Cerebral nuclei including the striatum, a hub for motivated behavior in amniotes, had molecularly conserved goldfish homologs. We suggest elements of a hippocampal formation across the goldfish pallium. Last, aiding study of the teleostan everted telencephalon, we describe substantial molecular similarities between goldfish and zebrafish neuronal taxonomies.
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