ArticleScience advances2023
AI-driven robotic chemist for autonomous synthesis of organic molecules.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- AI-Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery.Medicinal research reviews · 2026Review
- AIMNet2-rxn: A machine-learned potential for generalized reaction modeling on a millions-of-pathways scale.Science advances · 2026Article
- The past, present and future of self-driving laboratories.Nature reviews. Chemistry · 2026Review
- Machine Learning-Empowered Electromagnetic Wave Absorbing Materials: From Forward Prediction to Generative Inverse Design.Molecules (Basel, Switzerland) · 2026Review
- High-Throughput Methods in Materials Science (Part I): A Review of Chemical and Physical Methods and Automated Sample Logistics.Materials (Basel, Switzerland) · 2026Review
- Transforming Molecular Science With Large Language Models: From Molecule Understanding to Autonomous Scientific Discovery.Chemistry, an Asian journal · 2026Review
- Machine learning-driven discovery of optimal designs for water electrolysis devices.Science advances · 2026Article
- Antiferroelectric polarization enabling physical activation in CuBiPNature communications · 2026Article
- From Prompt to Drug: Toward Pharmaceutical Superintelligence.ACS central science · 2026Review
- MODNet: A Monocular Object-Based Depth Estimation Network for AI Robotic Chemists.Precision chemistry · 2026Article
- Synergizing Chemical and AI Communities for Advancing Laboratories of the Future.ACS central science · 2026Review
- Utilizing Similarity Measures to Map Chemical Reactivity.Angewandte Chemie (International ed. in English) · 2026Article
- Artificial intelligence in experimental and clinical in vitro analysis: applications, limitations, and future directions.Biotechnology notes (Amsterdam, Netherlands) · 2026Review
- Artificial Intelligence as a Disruptive Force in Pharmaceutical Innovation: Transforming Discovery, Development, and Manufacturing.Drug design, development and therapy · 2026Review
- Localization, inspection, and reasoning (LIRA) module for autonomous workflows in self-driving laboratories.Communications chemistry · 2025Article
- Diffusion Models at the Drug Discovery Frontier: A Review on Generating Small Molecules Versus Therapeutic Peptides.Biology · 2025Review
- A Visual Dataset for Anomaly Detection in Self-Driving Laboratories.Scientific data · 2025Article
- Optimized Machine Learning for Autonomous Enzymatic Reaction Intensification in a Self-Driving Lab.Biotechnology and bioengineering · 2025Article
- Data-driven recommendation of agents, temperature, and equivalence ratios for organic synthesis.Chemical science · 2025Article
- 33 Unresolved Questions in Nanoscience and Nanotechnology.ACS nano · 2025Article
Corrections and comments
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Authors and funding
28 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The automation of organic compound synthesis is pivotal for expediting the development of such compounds. In addition, enhancing development efficiency can be achieved by incorporating autonomous functions alongside automation. To achieve this, we developed an autonomous synthesis robot that harnesses the power of artificial intelligence (AI) and robotic technology to establish optimal synthetic recipes. Given a target molecule, our AI initially plans synthetic pathways and defines reaction conditions. It then iteratively refines these plans using feedback from the experimental robot, gradually optimizing the recipe. The system performance was validated by successfully determining synthetic recipes for three organic compounds, yielding that conversion rates that outperform existing references. Notably, this autonomous system is designed around batch reactors, making it accessible and valuable to chemists in standard laboratory settings, thereby streamlining research endeavors.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.