Evidence map›Paper›PMID 37910508›Full record

ArticleCell reports2023

Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation.

Dong Hoon Kang, Yerin Kim, Seongchun Min, Su Youn Lee, Ka Young Chung, In-Jeoung Baek, Kihwan Kwon, Hanjoong Jo, Sang Won Kang

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Nitrosation of CD36 Regulates Endothelial Function and Serum Lipids.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Dong Hoon KangDepartment of Life Science, Ewha Womans University, Seoul 03760, Republic of Korea.
Yerin KimDepartment of Life Science, Ewha Womans University, Seoul 03760, Republic of Korea.
Seongchun MinDepartment of Life Science, Ewha Womans University, Seoul 03760, Republic of Korea.
Su Youn LeeSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Ka Young ChungSchool of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
In-Jeoung BaekConvergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Kihwan KwonDepartment of Cardiology, College of Medicine, Ewha Womans University, Seoul 07804, Republic of Korea.
Hanjoong JoCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA.
Sang Won KangDepartment of Life Science, Ewha Womans University, Seoul 03760, Republic of Korea. Electronic address: kangsw@ewha.ac.kr.
Ewha Womans University · KRSungkyunkwan University · KRGeorgia Institute of Technology · USUlsan College · KR

Funding

Role of CEBPb in flow-dependent endothelial dysfunction and atherosclerosisR01HL168383 · NHLBI · EMORY UNIVERSITY · PI Hanjoong Jo · 2023 to 2026
$3.0M
HEG1 in endothelial function and atherosclerosisR01HL158571 · NHLBI · EMORY UNIVERSITY · PI JO, HANJOONG · 2021 to 2024
$2.7M
Role of flow-sensitive KLK10 in endothelial dysfunction and atherosclerosisR01HL139757 · NHLBI · EMORY UNIVERSITY · PI JO, HANJOONG · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL139757NHLBI NIH HHS R01 HL158571NHLBI NIH HHS R01 HL168383
6 · The paper itself

Abstract

Vascular endothelial growth factor receptor-2 (VEGFR2) plays a key role in maintaining vascular endothelial homeostasis. Here, we show that blood flows determine activation and inactivation of VEGFR2 through selective cysteine modifications. VEGFR2 activation is regulated by reversible oxidation at Cys

Indexed as

Endothelial CellsHydrogen PeroxideAnimalsEndothelium, VascularMiceOxidation-ReductionSignal TransductionVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2Hydrogen PeroxideKdr protein, mouseVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2CP: Cell biologyendothelial cellsendothelial NOSNOX4shear stressVEGFR2

Identifiers

PMID37910508
PMCPMC11869325
OpenAlexW4388112943

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.