ArticleCell reports2023
The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Attenuation of HIV-specific T cell responses Among people with HIV on ART following dipyridamole treatment.Journal of leukocyte biology · 2024Trial
- Efficient lentivirus concentration using a tabletop centrifuge.Molecular biology reports · 2026Article
- Spheroids reveal hypoxia‑driven spatial restriction of adenoviral infection.Scientific reports · 2026Article
- HIV Reservoirs Across Multiple Tissues: From Heterogeneous Mechanisms to Therapeutic Targeting.Microorganisms · 2026Review
- N1MΨU-modified mRNA vaccines break the mold in fish by enhancing innate immune activation.Molecular therapy. Nucleic acids · 2026Article
- microRNA-422a promotes HIV replication and innate immune evasion by targeting MECP2.Molecular therapy. Nucleic acids · 2026Article
- Development of Biocompatible Nanocarriers for Antiretrovirals Based on Polylactide and Chitosan.AAPS PharmSciTech · 2026Article
- Targeting ecto-5'-nucleotidase (CD73) and cAMP alleviates carotid body hyperactivity and reduces blood pressure in chronically hypoxic rats.The Journal of physiology · 2026Article
- Single-cell transcriptome profiling reveals immunological fitness of HIV long-term non-progressors.Journal of virology · 2025Article
- Trends and hotspots in research of virus and gastrointestinal mucosal immunity: a bibliometric analysis of four decades.Virology journal · 2025Article
- Pannexin-1 channels, extracellular ATP, and purinergic receptors are essential for CCR5/CXCR4 clustering and HIV entry.NeuroImmune pharmacology and therapeutics · 2025Article
- Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts.Nature communications · 2025Article
- Phenotyping Viral Reservoirs to Reveal HIV-1 Hiding Places.Current HIV/AIDS reports · 2025Review
- Bridging the gap with multispecific immune cell engagers in cancer and infectious diseases.Cellular & molecular immunology · 2024Review
- Mechanisms of HIV-mediated blood-brain barrier compromise and leukocyte transmigration under the current antiretroviral era.iScience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 2 countries.
Hannah S SperberVitalant Research Institute, San Francisco, CA, USA; Free University of Berlin, Institute of Biochemistry, Berlin, Germany; University of California, San Francisco, San Francisco, CA, USA; University Hospital Essen, Institute for Translational HIV Research, Essen, Germany.
Kyle A RaymondVitalant Research Institute, San Francisco, CA, USA; University of California, San Francisco, San Francisco, CA, USA.
Mohamed S BouzidiVitalant Research Institute, San Francisco, CA, USA; University of California, San Francisco, San Francisco, CA, USA.
Tongcui MaUniversity of California, San Francisco, San Francisco, CA, USA; Gladstone Institutes, San Francisco, CA, USA.
Silvana ValdebenitoThe University of Texas Medical Branch, Galveston, TX, USA.
Eliseo A EugeninThe University of Texas Medical Branch, Galveston, TX, USA.
Nadia R RoanUniversity of California, San Francisco, San Francisco, CA, USA; Gladstone Institutes, San Francisco, CA, USA.
Steven G DeeksUniversity of California, San Francisco, San Francisco, CA, USA.
Sandra WinningUniversity of Duisburg-Essen, Institute for Physiology, Essen, Germany.
Joachim FandreyUniversity of Duisburg-Essen, Institute for Physiology, Essen, Germany.
Roland SchwarzerUniversity Hospital Essen, Institute for Translational HIV Research, Essen, Germany. Electronic address: roland-schwarzer@gmx.de.
Satish K PillaiVitalant Research Institute, San Francisco, CA, USA; University of California, San Francisco, San Francisco, CA, USA. Electronic address: satish.pillai@ucsf.edu.
University of California, San Francisco · USEssen University Hospital · DEThe University of Texas Medical Branch at Galveston · USUniversity of Duisburg-Essen · DEVitalant · USGladstone Institutes · US
Funding
Delaney AIDS Research Enterprise to Cure HIVUM1AI164560 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS, Sharon Ruth Lewin · 2021 to 2026
$32.0MThe Manhattan HIV Brain BankU24MH100931 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORGELLO, SUSAN · 2013 to 2023
$14.0MCalifornia NeuroAIDS Tissue NetworkU24MH100928 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACHIM, CRISTIAN L, MOORE, DAVID J · 2013 to 2023
$13.9MNATIONAL NEUROLOGICAL AIDS BANKU24MH100929 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2013 to 2023
$12.5MTexas NeuroAIDS Research CenterU24MH100930 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GELMAN, BENJAMIN B. · 2013 to 2023
$12.1MAstrocyte connexin43 containing channels amplify CNS dysfunction in NeuroAIDSR01MH096625 · NIMH · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI EUGENIN, ELISEO A · 2012 to 2020
$4.5MPhenotypic and mechanistic analysis of the in vivo HIV latent reservoir by single-cell technologiesR01AI147777 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROAN, NADIA R · 2019 to 2022
$3.8MRole of pannexin-1 hemichannels in NeuroAIDSR01NS105584 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI EUGENIN, ELISEO A · 2017 to 2021
$3.2MMetabolic strategies to eliminate CNS Myeloid Viral ReservoirsR01MH128082 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI EUGENIN, ELISEO A · 2021 to 2025
$3.1MTargeting cell-to-cell communication to prevent bystander damage mediated by viral reservoirsR01MH134761 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Eliseo A Eugenin · 2024 to 2026
$2.1MElucidating the mechanism of progesterone-induced permissivity in the upperfemale reproductive tractR01AI127219 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROAN, NADIA R · 2016 to 2020
$2.1MEffects of Human Galectin-9 on the CNS HIV ReservoirR01MH112457 · NIMH · VITALANT · PI NDHLOVU, LISHOMWA C, PILLAI, SATISH KUMAR · 2016 to 2020
$2.0MNIAID NIH HHS R01 AI064559NIAID NIH HHS R01 AI127219NIAID NIH HHS R01 AI147777NIAID NIH HHS R01 AI150449NIAID NIH HHS R56 AI064559NIAID NIH HHS UM1 AI164560NIMH NIH HHS R01 MH096625NIMH NIH HHS R01 MH112457NIMH NIH HHS R01 MH128082NIMH NIH HHS R01 MH134761NIMH NIH HHS U24 MH100928NIMH NIH HHS U24 MH100929NIMH NIH HHS U24 MH100930NIMH NIH HHS U24 MH100931NINDS NIH HHS R01 NS105584
Abstract
Deciphering the mechanisms underlying viral persistence is critical to achieving a cure for human immunodeficiency virus (HIV) infection. Here, we implement a systems approach to discover molecular signatures of HIV latently infected CD4
Indexed as
HIV-1HIV Infections5'-NucleotidaseAdenosineCD4-Positive T-LymphocytesGPI-Linked ProteinsHumansVirus ActivationVirus LatencyVirus Replication5'-NucleotidaseAdenosineGPI-Linked ProteinsNT5E protein, humanadenosineCD39CD73CP: ImmunologyCP: MicrobiologyeradicationHIV curehypoxiaIL-8lymphoid tissuespersistencereservoir
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.