Evidence map›Paper›PMID 37910452›Full record

ArticlePLOS global public health2023

Adherence to antiretroviral therapy among HIV patients in Ghana: A systematic review and meta-analysis.

Isaac Boadu, Adom Manu, Richmond Nii Okai Aryeetey, Kwame Adjei Kesse, Marijanatu Abdulai, Emmanuel Acheampong, Robert Akparibo

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Article in PLOS global public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. Responsibilities and Challenges of Models of Hope in the HIV/AIDS Care-giving Continuum in Ghana.Journal of the International Association of Providers of AIDS Care
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Isaac BoaduDepartment of Population, Family and Reproductive Health, School of Public Health, Legon, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0003-2703-7391
Adom ManuDepartment of Population, Family and Reproductive Health, School of Public Health, Legon, University of Ghana, Accra, Ghana.
Richmond Nii Okai AryeeteyDepartment of Population, Family and Reproductive Health, School of Public Health, Legon, University of Ghana, Accra, Ghana.
Kwame Adjei KesseDepartment of Population, Family and Reproductive Health, School of Public Health, Legon, University of Ghana, Accra, Ghana.
Marijanatu AbdulaiDepartment of Epidemiology and Disease Control, School of Public Health, Legon, University of Ghana, Accra, Ghana.
Emmanuel AcheampongInstitute of Precision Health, University of Leicester, Leicester, United Kingdom.
Robert AkpariboSchool of Health and Related Research (ScHARR), University of Sheffield, Sheffield, United Kingdom.ORCID https://orcid.org/0000-0003-3751-2432

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maintaining a high level of adherence to antiretroviral therapy (ART) is critical to limiting rapid viral replication, drug resistance, and viral transmission. However, ART adherence remains a major challenge in HIV/AIDS treatment success. This systematic review and meta-analysis was aimed to synthesize available evidence on adherence to ART among HIV/AIDS patients in Ghana.This review followed the preferred reporting item for systematic review and meta-analysis (PRISMA) criteria. A comprehensive literature search was done using five online databases (PubMed, Google Scholar, Medline, Africa Index Medicus, and Willey Online Library) from 25th- 30th April 2023 to identify potential studies. In addition, references of related articles were manually searched to further identify relevant studies. Search records were managed in Endnote library where duplicates were removed prior to screening. Studies were eligible for inclusion if they were conducted in Ghana, designed as an observational or experimental study, and explicitly measured adherence to ART, either as a primary or secondary outcome. Studies were excluded if the proportion or prevalence of adherence to ART was not reported.A total number of 126 potential studies were identified from the literature search. Of these, 14 met the inclusion criteria and were included in the Meta-analysis. The studies involved a total number of 4,436 participants. The pooled estimate of adherence to ART was 70% (CI: 58-81%). In subgroup analysis, adolescents and young adults had a lower adherence rate (66%, CI: 46-84%) compared with adults (70%; CI: 58-81%). Publication bias was not observed among studies. The pooled estimate of optimal adherence to ART among HIV patients in Ghana was lower than is recommended (≥95%) to achieve viral suppression. Adherence was lower among young persons living with HIV/AIDS. To achieve the United Nation's Sustainable development goals and the UNAIDS "95-95-95" targets, there is a need to focus on improving adherence interventions among persons living with HIV/AIDS, especially among the younger cohort.

Identifiers

PMID37910452
PMCPMC10619784

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.