ArticleAging clinical and experimental research2023
Differential eye movement features between Alzheimer's disease patients with and without depressive symptoms.
Article in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Eye tracking as a digital biomarker in neurodegenerative diseases.Journal of neurology · 2026Review
- Efficacy of high-frequency rTMS in the treatment of gait disorder and cognition in patients with Parkinson's disease based on wearable devices and eye-movement assessments.Frontiers in aging neuroscience · 2024Article
- Abnormal eye movements: relationship with clinical symptoms and predictive value for Alzheimer's disease.Frontiers in aging neuroscience · 2024Article
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7 authors.
Funding
Abstract
backgroundAccurately diagnosing depressive symptoms in Alzheimer's disease (AD) patients is often challenging. Eye movement parameters have been demonstrated as biomarkers for assessing cognition and psychological conditions.
aimTo investigate the differences in eye movement between AD patients with and without depressive symptoms.
methodsEye movement data of 65 AD patients were compared between the depressed AD (D-AD) and non-depressed AD (nD-AD) groups. Logistic regression analysis was employed to identify diagnostic biomarkers and the ROC curve was plotted. The correlation between eye movement and HAMD-17 scores was assessed by partial correlation analysis.
resultsThe D-AD patients showed longer saccade latency and faster average/peak saccade velocities in the overlap prosaccade test, longer average reaction time and faster average saccade velocity in the gap prosaccade test, longer start-up durations, slower pursuit velocity, more offsets, and larger total offset degrees in the smooth pursuit test, and poorer fixation stability in both the central and lateral fixation tests compared to nD-AD patients. The start-up duration in the smooth pursuit test and the number of offsets in the central fixation test were identified as the diagnostic eye movement parameters for D-AD patients with the area under the ROC curves of 0.8011. Partial correlation analysis revealed that the start-up duration and pursuit velocity in the smooth pursuit test and the total offset degrees in the lateral fixation test were correlated with HAMD-17 scores in D-AD patients. DISCUSSION AND
conclusionsEye movement differences may help to differentiate D-AD patients from nD-AD patients in a non-invasive and cost-effective manner.
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