Evidence map›Paper›PMID 37910250›Full record

ArticleJournal of neurology2024

Quantitative brainstem and spinal MRI in amyotrophic lateral sclerosis: implications for predicting noninvasive ventilation needs.

M Khamaysa, M Lefort, M Pélégrini-Issac, A Lackmy-Vallée, M M El Mendili, A Preuilh, D Devos, G Bruneteau, F Salachas, T Lenglet and 13 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 13 institutions in 2 countries.

M KhamaysaSorbonne Université, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France.
M LefortSorbonne Université, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France.
M Pélégrini-IssacSorbonne Université, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France.
A Lackmy-ValléeSorbonne Université, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France.
M M El MendiliAPHM, Hôpital Timone, CEMEREM, Marseille, France.
A PreuilhSorbonne Université, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France.
D DevosDépartement de Neurologie, Centre Référent SLA, CHU de Lille, Centre LICEND COEN, ACT4-ALS-MND network, Lille, France.
G BruneteauAPHP, Département de Neurologie, Hôpital Pitié-Salpêtrière, Centre Référent SLA, Paris, France.
F SalachasAPHP, Département de Neurologie, Hôpital Pitié-Salpêtrière, Centre Référent SLA, Paris, France.
T LengletAPHP, Département de Neurologie, Hôpital Pitié-Salpêtrière, Centre Référent SLA, Paris, France.
Md M AmadorAPHP, Département de Neurologie, Hôpital Pitié-Salpêtrière, Centre Référent SLA, Paris, France.
N Le ForestierAPHP, Département de Neurologie, Hôpital Pitié-Salpêtrière, Centre Référent SLA, Paris, France.
A HestersAPHP, Département de Neurologie, Hôpital Pitié-Salpêtrière, Centre Référent SLA, Paris, France.
J GonzalezNeurophysiologie Respiratoire Expérimentale et Clinique, INSERM UMRS1158, Sorbonne Université, Paris, France.
A-S RollandDépartment de Pharmacologie Médicale, Université de Lille, INSERM UMRS_1172 LilNCog, CHU de Lille, Centre LICEND COEN, ACT4-ALS-MND network, Lille, France.
C DesnuelleFaculté de Médecine de Nice, Département de Neurologie, Université Cote d'Azur, Nice, France.
M ChupinCATI, Plateforme d'Imagerie Neurologique Multicentrique, Paris, France.
G QuerinAPHP, Service de Neuromyologie, Hôpital Pitié-Salpêtrière, Centre Référent Pour les Maladies Neuromusculaires Rares, Paris, France.
M GeorgesDépartement des Maladies Respiratoires et Soins Intensifs, Centre de Référence pour les Maladies Pulmonaires Rares, Hôpital Universitaire de Dijon-Bourgogne, Dijon, France.
C Morelot-PanziniNeurophysiologie Respiratoire Expérimentale et Clinique, INSERM UMRS1158, Sorbonne Université, Paris, France.
V Marchand-Pauvert *Sorbonne Université, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France.
P-F Pradat *Sorbonne Université, CNRS, INSERM, Laboratoire d'Imagerie Biomédicale, Paris, France. pierre-francois.pradat@aphp.fr.
Pulse Study Group
Inserm · FRAssistance Publique – Hôpitaux de Paris · FRPitié-Salpêtrière Hospital · FRSorbonne Université · FRCentre d'Acquisition et de Traitement des ImagesCentre de Résonance Magnétique Biologique et Médicale · FRCentre Hospitalier Universitaire de Lille · FRCentre Hospitalier Universitaire Dijon Bourgogne · FRInstitut de Myologie · FRLaboratoire d’Imagerie Biomédicale · FRUniversité Côte d'Azur · FRUniversité Paris-Sud · FRUniversity of Ulster · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespiratory complications resulting from motor neurons degeneration are the primary cause of death in amyotrophic lateral sclerosis (ALS). Predicting the need for non-invasive ventilation (NIV) in ALS is important for advance care planning and clinical trial design. The aim of this study was to assess the potential of quantitative MRI at the brainstem and spinal cord levels to predict the need for NIV during the first six months after diagnosis.

methodsForty-one ALS patients underwent MRI and spirometry shortly after diagnosis. The need for NIV was monitored according to French health guidelines for 6 months. The performance of four regression models based on: clinical variables, brainstem structures volumes, cervical spinal measurements, and combined variables were compared to predict the need for NIV within this period.

resultsBoth the clinical model (R

conclusionsOur study shows that brainstem volumes and spinal cord area are promising measures to predict respiratory intervention needs in ALS.

Indexed as

Amyotrophic Lateral SclerosisNoninvasive VentilationBrain StemDisease ProgressionHumansMagnetic Resonance ImagingAmyotrophic lateral sclerosisBiomarkersBrainstemMotor neuron disorderMRINon-invasive ventilationSpinal cordSpirometry

Identifiers

PMID37910250
OpenAlexW4388183668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.