Evidence map›Paper›PMID 37910165›Full record

ArticleThe Journal of general virology2023

Structure and immunogenicity of the murine astrovirus capsid spike.

Sarah Lanning, Natalie Pedicino, Danielle J Haley, Samuel Hernandez, Valerie Cortez, Rebecca M DuBois

Open access · greenAbstract read
In one paragraph

Article in The Journal of general virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sarah LanningDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA.
Natalie PedicinoDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA.
Danielle J HaleyDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA.
Samuel HernandezDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA.
Valerie CortezDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA.
Rebecca M DuBoisDepartment of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA.
University of California, Santa Cruz · US

Funding

Training Program in Molecular, Cell, and Developmental BiologyT32GM133391 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Needhi Bhalla · 2019 to 2026
$3.0M
UC San Diego RAPID Faculty Development Program in Infectious DiseasesR25AI147376 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ADRIANA H TREMOULET, Joann Trejo · 2020 to 2026
$2.5M
Structural, mechanistic, and antigenic insights into the human astrovirus capsidR01AI144090 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI DUBOIS, REBECCA MICHELLE · 2019 to 2023
$2.2M
Astrovirus modulation of gut immunity via goblet cellsK22AI156116 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CORTEZ, VALERIE · 2021 to 2022
$312k
NIAID NIH HHS K22 AI156116NIAID NIH HHS R01 AI144090NIAID NIH HHS R25 AI147376NIGMS NIH HHS T32 GM133391
6 · The paper itself

Abstract

Human astroviruses (HAstVs) are small, non-enveloped icosahedral RNA viruses that are a significant cause of diarrhoea in young children. Despite their worldwide prevalence, HAstV pathogenesis studies and vaccine development remain challenging due to the lack of an animal model for HAstV infection. The recent development of a murine astrovirus (MuAstV) infection model in mice provides the opportunity to test proof-of-concept vaccines based on MuAstV antigens. To help establish a system in which an astrovirus capsid spike-based vaccine could be tested

Indexed as

AstroviridaeAstroviridae InfectionsVaccinesAnimalsCapsidCapsid ProteinsChildChild, PreschoolHumansMiceCapsid ProteinsVaccinesastrovirusesmurine astrovirusspike proteinviral capsidvirus structure

Identifiers

PMID37910165
PMCPMC10773150
OpenAlexW4388129763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.