Article in The Journal of experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors.
Michael Solomon *Division of Experimental Hematology and Cancer Biology, Stem Cell Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0009-0001-6258-0931
Baobao Song *Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-0062-2710
Vinothini GovindarajahDivision of Experimental Hematology and Cancer Biology, Stem Cell Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0009-0008-9994-0786
Samantha GoodDivision of Experimental Hematology and Cancer Biology, Stem Cell Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0009-0003-5076-7680
Ashok ArasuDivision of Experimental Hematology and Cancer Biology, Stem Cell Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-5827-2290
E Broderick HintonDivision of Experimental Hematology and Cancer Biology, Stem Cell Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0009-0008-2730-7674
Kairavee ThakkarDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0003-1397-486X
James BartramDivision of Experimental Hematology and Cancer Biology, Stem Cell Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-9081-4088
Marie-Dominique FilippiDivision of Experimental Hematology and Cancer Biology, Stem Cell Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-7808-0237
Jose A CancelasDivision of Experimental Hematology and Cancer Biology, Stem Cell Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-1291-7233
Nathan SalomonisDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-9689-2469
H Leighton GrimesDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-8162-6758
Damien ReynaudDivision of Experimental Hematology and Cancer Biology, Stem Cell Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-8765-8419
Funding
ENVIRONMETAL CARCINOGENESIS AND MUTAGENESIST32ES007250 · NIEHS · UNIVERSITY OF CINCINNATI · PI MILLER, WILLIAM E · 1988 to 2024
$11.9M
Mechanisms of granulocyte homeostasisR01HL122661 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI H. LEIGHTON GRIMES, Nathan G. Salomonis · 2015 to 2026
$5.3M
A generalizable framework for linking single-cell genomic states with cell fate outcomes in hematopoiesisRC2DK122376 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI GRIMES, H. LEIGHTON · 2020 to 2024
$5.3M
Xenotransplant and Genome Editing CoreU54DK126108 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Daniel Starczynowski, YI ZHENG · 2021 to 2026
$5.0M
The role of mitochondria in hematopoietic stem cell self-renewalR01HL151654 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI FILIPPI, MARIE-DOMINIQUE · 2021 to 2024
$2.4M
Regulation of functionally discrete hematopietic stem cellsR01DK121062 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI FILIPPI, MARIE-DOMINIQUE, GRIMES, H. LEIGHTON · 2020 to 2023
$2.3M
Diabetic Memory in Hematopoietic Stem CellsR01DK133145 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Damien Reynaud · 2023 to 2026
$1.7M
Normal and Pathological Hematopoietic Stem Cells in ObesityR01HL141418 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI REYNAUD, DAMIEN · 2018 to 2021
$1.6M
ZE5 Analytical CytometerS10OD025045 · OD · CINCINNATI CHILDRENS HOSP MED CTR · PI THORNTON, SHERRY L · 2018 to 2018
The dynamics of the hematopoietic flux responsible for blood cell production in native conditions remains a matter of debate. Using CITE-seq analyses, we uncovered a distinct progenitor population that displays a cell cycle gene signature similar to the one found in quiescent hematopoietic stem cells. We further determined that the CD62L marker can be used to phenotypically enrich this population in the Flt3+ multipotent progenitor (MPP4) compartment. Functional in vitro and in vivo analyses validated the heterogeneity of the MPP4 compartment and established the quiescent/slow-cycling properties of the CD62L- MPP4 cells. Furthermore, studies under native conditions revealed a novel hierarchical organization of the MPP compartments in which quiescent/slow-cycling MPP4 cells sustain a prolonged hematopoietic activity at steady-state while giving rise to other lineage-biased MPP populations. Altogether, our data characterize a durable and productive quiescent/slow-cycling hematopoietic intermediary within the MPP4 compartment and highlight early paths of progenitor differentiation during unperturbed hematopoiesis.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions. · full record | OpenQuestion