Evidence map›Paper›PMID 37909854›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2023

Metabolic consequences of skeletal muscle- and liver-specific BBSome deficiency.

Younes Rouabhi, Deng-Fu Guo, Yuying Zhao, Kamal Rahmouni

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Adipocyte-specific disruption of the BBSome causes metabolic and autonomic dysfunction.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Younes RouabhiDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States.
Deng-Fu GuoDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States.
Yuying ZhaoDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States.
Kamal RahmouniDepartment of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States.ORCID 0000-0001-5136-6748
University of Iowa · US

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2007 to 2022
$30.2M
Role of FGF21 Action in Hypothalamic Neurons in Obesity-Associated HypertensionR01HL162773 · NHLBI · UNIVERSITY OF IOWA · PI KAMAL RAHMOUNI · 2023 to 2026
$2.4M
Medical Student Summer Research ProgramT35HL166206 · NHLBI · UNIVERSITY OF IOWA · PI ROBERT D ROGHAIR · 2023 to 2026
$598k
BLRD VA I01 BX004249BLRD VA IK6 BX006040NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL162773NHLBI NIH HHS T35 HL166206
6 · The paper itself

Abstract

The BBSome is a protein complex composed of eight Bardet-Biedl syndrome (BBS) proteins including BBS1. Humans and mice lacking a functional BBSome display obesity and type 2 diabetes, highlighting the importance of this protein complex for metabolic regulation. However, the contribution of the BBSome in insulin-sensitive tissues such as skeletal muscle and liver to metabolic regulation is ill-defined. Here, we show that disruption of the BBSome through

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceInsulinsAnimalsBardet-Biedl SyndromeBody WeightFemaleGlucoseHumansLiverMaleMiceMicrotubule-Associated ProteinsMuscle, SkeletalObesityReceptor, InsulinBbs1 protein, humanGlucoseInsulinsMicrotubule-Associated ProteinsReceptor, InsulinBardet–Biedl syndrome proteinsenergy balanceinsulin sensitivityliverskeletal muscle

Identifiers

PMID37909854
PMCPMC10864019
OpenAlexW4388141272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.