Evidence map›Paper›PMID 37909750›Full record

ArticleInfection and immunity2023

Involvement of endoplasmic reticulum and histone proteins in immunomodulation by TLR4-interacting SPA4 peptide against

Shanjana Awasthi, Bhupinder Singh, Vijay Ramani, Nachiket M Godbole, Catherine King

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shanjana AwasthiDepartment of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID 0000-0003-1249-0708
Bhupinder SinghDepartment of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Vijay RamaniDepartment of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Nachiket M GodboleDepartment of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Catherine KingDepartment of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
University of Oklahoma Health Sciences Center · US

Funding

Surfactant protein-A regions as TLR4-immunomodulatorsR01HL136325 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI AWASTHI, SHANJANA · 2017 to 2021
$1.8M
NHLBI NIH HHS R01 HL136325
6 · The paper itself

Abstract

Pulmonary host defense is critical for the control of lung infection and inflammation. An increased expression and activity of Toll-like receptor 4 (TLR4) induce phagocytic uptake/clearance and inflammation against Gram-negative bacteria. In this study, we addressed the mechanistic aspect of the immunomodulatory activity of the TLR4-interacting SPA4 peptide (amino acid sequence GDFRYSDGTPVNYTNWYRGE) against

Indexed as

Escherichia coliToll-Like Receptor 4CalnexinEndoplasmic ReticulumHistonesHumansInflammationLipopolysaccharidesTumor Necrosis Factor-alphaCalnexinHistonesLipopolysaccharidesTLR4 protein, humanToll-Like Receptor 4Tumor Necrosis Factor-alphabacterial phagocytosisEscherichia colihost defenseinflammationsurfactant protein A-derived peptideToll-like receptor 4

Identifiers

PMID37909750
PMCPMC10714950
OpenAlexW4388128087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.