ArticleEnvironmental health perspectives2023
Global Air Pollutant Phenanthrene and Arrhythmic Outcomes in a Mouse Model.
Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- 4-Hydroxyphenanthrene exacerbates obesity by altering gut microbiota and bile acid metabolism.Nature communications · 2026Article
- The air pollutant phenanthrene disrupts calcium cycling and alters repolarization in female sheep ventricular cardiomyocytes.Physiological reports · 2025Article
- The Effects of 3-Methylphenanthrene on Ion Currents Mediated by KBulletin of experimental biology and medicine · 2025Article
- Mapping the research landscape of artificial hearts: identifying hotspots and frontiers through bibliometric analysis.Frontiers in cardiovascular medicine · 2025Review
- Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60-69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study.Environmental health perspectives · 2024Article
- Association of mixed polycyclic aromatic hydrocarbons exposure with cardiovascular disease and the mediating role of inflammatory indices in US adults.Environmental health and preventive medicine · 2024Article
- Invited Perspective: The Silent Threat-Air Pollution's Link to Arrhythmias.Environmental health perspectives · 2023Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe three-ringed polycyclic aromatic hydrocarbon (PAH) phenanthrene (Phe) has been implicated in the cardiotoxicity of petroleum-based pollution in aquatic systems, where it disrupts the contractile and electrical function of the fish heart. Phe is also found adsorbed to particulate matter and in the gas phase of air pollution, but to date, no studies have investigated the impact of Phe on mammalian cardiac function.
objectivesOur objectives were to determine the arrhythmogenic potential of acute Phe exposure on mammalian cardiac function and define the underlying mechanisms to provide insight into the toxicity risk to humans.
methods
resultsMouse hearts exposed to DISCUSSION: To the best of our knowledge, this is the first evidence of direct inhibitory effects of Phe on mammalian cardiac electrical activity at both the whole-heart and cell levels. This electrical dysfunction manifested as an increase in arrhythmia susceptibility due to impairment of both conduction and repolarization. Similar effects in humans could have serious health consequences, warranting greater regulatory attention and toxicological investigation into this ubiquitous PAH pollutant generated from fossil-fuel combustion. https://doi.org/10.1289/EHP12775.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.