Trial reportJournal of applied oral science : revista FOB2023
In-office dental bleaching in adolescents using 6% hydrogen peroxide with different application tips: randomized clinical trial.
Trial report in Journal of applied oral science : revista FOB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Efficacy and Tooth Sensitivity of Low- Versus High-Concentration Hydrogen Peroxide for In-Office Bleaching: A Randomized Clinical Trial.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Trial
- Efficacy and safety of low-concentration whitestrips for extrinsic tooth discoloration: a randomized controlled trial.Frontiers in oral health · 2026Trial
- Influence of Different Protocols on In-Office Bleaching: Whiteness Difference and Hydrogen Peroxide Penetration.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025Trial
- Effect of personality characteristics on perception of tooth whitening outcome in young adults in long-term: a randomised, double-blind, placebo controlled trial.Head & face medicine · 2025Trial
- Clinical evaluation of in-office bleaching with low, medium, and high concentrate hydrogen peroxide: a 6-month a double-blinded randomized controlled trial.Clinical oral investigations · 2025Trial
- In-office dental bleaching in adolescents using 6% hydrogen peroxide with and without gingival barrier: a randomized double-blind clinical trial.Journal of applied oral science : revista FOB · 2024Trial
- Effect of Applicator Brush Use on Color Change, Hydrogen Peroxide Penetration, and Gel Consumption in In-Office Bleaching: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- Do bleaching gels supplied in attachable syringes maintain their bleaching efficacy 72 hours after mixing?Clinical oral investigations · 2026Article
- In situ evaluation of the bleaching efficacy of experimental hydrogen peroxide hydrogel with MnO-doped Biosilicate activated by violet LED light.European journal of oral sciences · 2026Article
- Clinical myths in dental bleaching: an evidence-based structured narrative review.Brazilian oral research · 2026Review
- Peroxide-Free Titanium Dioxide Nanoparticle-Based Photocatalytic Bleaching: In Vitro Study on Bovine Teeth.BioMed research international · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDespite the availability of in-office bleaching gels with a 6% concentration of hydrogen peroxide (HP), these gels have not been evaluated in younger patients. They are commercially available with a tip, associated or not with a brush, where the tip with a brush spreads the gel over the entire surface to have a smaller thickness (thin layer) since the manufacturers indicate the application of a thin layer of gel. This randomized, split-mouth, double-blind clinical trial evaluated the efficacy of in-office bleaching with 6% HP in adolescents using different application tips, as well tooth sensitivity (TS) and aesthetic self-perception. METHODOLOGY: Sixty participants were randomized for 6% HP self-mixing bleaching gel tip design: without brush and with brush. In-office bleaching was performed in 3 sessions of 50 minutes. Color change was evaluated using a digital spectrophotometer (ΔE ab , ΔE 00 , and ΔWI D ) and color guide (ΔSGU), the absolute risk and intensity of TS with a visual analogue scale and aesthetic self-perception with the oral aesthetic scale (a=0.05).
resultsThe groups achieved similar bleaching regardless of the application tip (p>0.05). However, only for ΔWI D , a significant mean difference (MD) was observed in the third week (MD 2.3; 95% CI 1.2 to 3.3; p < 0.001) and at one month (MD 1.6; 95% CI 0.6 to 2.6; p < 0.03) favoring the tip without brush. Regarding TS, 45% in the tip-without-brush group and 33% in the tip-with-brush group reported TS (odds ratio 0.61; 95% CI 0.29 to 1.28; p<0.02), with low TS intensity (MD 0.05; 95% CI -0.06 to 0.17; p>0.36). All patients reported improved aesthetic self-perception after bleaching (MD -1.3; 95% -1.8 to -0.9; p<0.001).
conclusionsRegardless of the tip used bleaching with 6% HP achieved a bleaching efficacy and improved the aesthetic self-perception. However, a lower risk of TS for application using the tip with brush was observed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.