Evidence map›Paper›PMID 37909221›Full record

ArticleHypertension (Dallas, Tex. : 1979)2024

Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na

Xin-Peng Duan, Yu Xiao, Xiao-Tong Su, Jun-Ya Zheng, Susan Gurley, Jacqueline Emathinger, Chao-Ling Yang, James McCormick, David H Ellison, Dao-Hong Lin and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Mechanistic target of rapamycin complex-1 plays a role in inhibiting kidney KAmerican journal of physiology. Renal physiology · 2026
    Article
  3. Mechanistic target of rapamycin complex-2 mediates the effect of overnight high KAmerican journal of physiology. Renal physiology · 2026
    Article
  4. Article
  5. Angiotensin II-Type-1a Receptor and Renal K + Wasting during Overnight Low-Na + Intake.Journal of the American Society of Nephrology : JASN · 2024
    Article
  6. Role of calcineurin in regulating renal potassium (KActa physiologica (Oxford, England) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Xin-Peng DuanDepartment of Physiology, Xuzhou Medical University, China (X.-P.D.).ORCID 0000-0003-2251-9607
Yu XiaoDepartment of Physiology, Qiqihar Medical College, Heilongjiang, China (Y.X.).
Xiao-Tong SuDepartment of Medicine, Oregon Health & Science University, Portland (X.-T.S., S.G., J.E., C.-L.Y., J.M., D.H.E.).ORCID 0000-0001-8121-8105
Jun-Ya ZhengDepartment of Pharmacology, New York Medical College, Valhalla (X.-P.D., Y.X., J.-Y.Z., D.-H.L., W.-H.W.).
Susan GurleyDepartment of Medicine, Oregon Health & Science University, Portland (X.-T.S., S.G., J.E., C.-L.Y., J.M., D.H.E.).
Jacqueline EmathingerDepartment of Medicine, Oregon Health & Science University, Portland (X.-T.S., S.G., J.E., C.-L.Y., J.M., D.H.E.).ORCID 0000-0002-6362-1133
Chao-Ling YangDepartment of Medicine, Oregon Health & Science University, Portland (X.-T.S., S.G., J.E., C.-L.Y., J.M., D.H.E.).
James McCormickDepartment of Medicine, Oregon Health & Science University, Portland (X.-T.S., S.G., J.E., C.-L.Y., J.M., D.H.E.).ORCID 0000-0003-4000-6653
David H EllisonDepartment of Medicine, Oregon Health & Science University, Portland (X.-T.S., S.G., J.E., C.-L.Y., J.M., D.H.E.).ORCID 0000-0003-2915-265X
Dao-Hong LinDepartment of Pharmacology, New York Medical College, Valhalla (X.-P.D., Y.X., J.-Y.Z., D.-H.L., W.-H.W.).ORCID 0000-0003-1760-2684
Wen-Hui WangDepartment of Pharmacology, New York Medical College, Valhalla (X.-P.D., Y.X., J.-Y.Z., D.-H.L., W.-H.W.).ORCID 0000-0002-7503-9554
Oregon Health & Science University · USNew York Medical College · USXuzhou Medical College · CN

Funding

Role of Kir4.1 in regulating NCC and ROMK in DCTR01DK133220 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID HOADLEY, WANG, WENHUI · 2022 to 2025
$2.6M
Regulation of Kir4.1/Kir5.1 and renal potassium excretionR01DK136491 · NIDDK · NEW YORK MEDICAL COLLEGE · PI Dao-Hong Lin · 2023 to 2026
$1.4M
NIDDK NIH HHS R01 DK133220NIDDK NIH HHS R01 DK136491
6 · The paper itself

Abstract

backgroundKir4.2 and Kir4.1 play a role in regulating membrane transport in the proximal tubule (PT) and in the distal-convoluted-tubule (DCT), respectively.

methodsWe generated kidney-tubule-specific-AT1aR-knockout (Ks-AT1aR-KO) mice to examine whether renal AT1aR regulates Kir4.2 and Kir4.1.

resultsKs-AT1aR-KO mice had a lower systolic blood pressure than

conclusionsAT1aR determines the baseline membrane potential of PT by controlling Kir4.2 expression/activity but AT1aR is not required for determining the baseline membrane potential of the DCT and Kir4.1/Kir5.1 activity/expression. However, AT1aR is required for angiotensin II-induced hyperpolarization of basolateral membrane of PT and DCT. Deletion of AT1aR had no effect on baseline renal outer medullary potassium channel activity but increased ENaC activity in the CCD.

Indexed as

Potassium Channels, Inwardly RectifyingReceptor, Angiotensin, Type 1Angiotensin IIAnimalsEpithelial Sodium ChannelsKcnj10 ChannelKidney TubulesKidney Tubules, DistalMiceMice, KnockoutPotassiumSodiumAgtr1a protein, mouseAngiotensin IIEpithelial Sodium ChannelsKcnj10 ChannelKir4.2 channelPotassiumPotassium Channels, Inwardly RectifyingReceptor, Angiotensin, Type 1Sodiumamilorideangiotensin IIgenotypeknockout miceperfusion

Identifiers

PMID37909221
PMCPMC10842168
OpenAlexW4388112519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.