Evidence map›Paper›PMID 37908859›Full record

ArticleHemaSphere2023

Prediction of the Clinical Course of Immune Thrombocytopenia in Children by Platelet Kinetics.

Julien Lejeune, Violette Raoult, Mathilde Dubrasquet, Romane Chauvin, Coralie Mallebranche, Isabelle Pellier, Françoise Monceaux, Sophie Bayart, Audrey Grain, Emmanuel Gyan and 3 more

Open access · goldAbstract read
In one paragraph

Article in HemaSphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Julien LejeunePediatric Onco-Hematology Unit, CHU de Tours, France.
Violette RaoultPediatric Onco-Hematology Unit, CHU de Tours, France.
Mathilde DubrasquetPediatric Onco-Hematology Unit, CHU de Tours, France.
Romane ChauvinPediatric Onco-Hematology Unit, CHU de Tours, France.
Coralie MallebranchePediatric Immuno-Hemato-Oncology Unit, CHU Angers, France.
Isabelle PellierPediatric Immuno-Hemato-Oncology Unit, CHU Angers, France.
Françoise MonceauxPediatric Unit, CH Orléans, France.
Sophie BayartPediatric and Adolescent Unit, CHRU de Rennes, France.
Audrey GrainPediatric Immuno-Hemato-Oncology Unit, CHU Nantes, France.
Emmanuel GyanPediatric Onco-Hematology Unit, CHU de Tours, France.
Noémie RavaletCNRS ERL7001, EA 7501 GICC, University of Tours, France.
Olivier HeraultCNRS ERL7001, EA 7501 GICC, University of Tours, France.
David TernantEA 7501 « Transplantation, Immunology, Inflammation », University of Tours, France.
Centre Hospitalier Universitaire de Tours · FRUniversité de Tours · FRCentre Hospitalier Universitaire d'Angers · FRCentre National de la Recherche Scientifique · FRCentre Hospitalier Guillaume Régnier · FRCentre hospitalier régional d'Orléans · FRCentre Hospitalier Universitaire de Nantes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Childhood immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by isolated thrombocytopenia. Prolonged ITP (persistent and chronic) leads to a reduced quality of life for children in many domains. To provide optimal support for children, with ITP, it is important to be able to predict those who will develop prolonged ITP. This study aimed to develop a mathematical model based on platelet recovery that allows the early prediction of prolonged ITP. In this retrospective study, we used platelet counts from the 6 months following the diagnosis of ITP to model the kinetics of change in platelet count using a pharmacokinetic-pharmacodynamic model. In a learning set (n = 103), platelet counts were satisfactorily described by our kinetic model. The K

Identifiers

PMID37908859
PMCPMC10615561
OpenAlexW4387968972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.