Evidence map›Paper›PMID 37908849›Full record

ArticleFrontiers in medicine2023

Distinct temporal trajectories and risk factors for Post-acute sequelae of SARS-CoV-2 infection.

Chen Chen, Sairam Parthasarathy, Jacqueline M Leung, Michelle J Wu, Katherine A Drake, Vanessa K Ridaura, Howard C Zisser, William A Conrad, Victor F Tapson, James N Moy and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 1 country.

Chen Chen *Verily Life Sciences, South San Francisco, CA, United States.
Sairam Parthasarathy *Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, AZ, United States.
Jacqueline M LeungVerily Life Sciences, South San Francisco, CA, United States.
Michelle J WuVerily Life Sciences, South San Francisco, CA, United States.
Katherine A DrakeVerily Life Sciences, South San Francisco, CA, United States.
Vanessa K RidauraVerily Life Sciences, South San Francisco, CA, United States.
Howard C ZisserVerily Life Sciences, South San Francisco, CA, United States.
William A ConradProvidence Little Company of Mary Medical Center Torrance, Torrance, CA, United States.
Victor F TapsonDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
James N MoyDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL, United States.
Christopher R deFilippiInova Heart and Vascular Institute, Falls Church, VA, United States.
Ivan O RosasDepartment of Medicine, Baylor College of Medicine, Houston, TX, United States.
Bellur S PrabhakarDepartment of Microbiology and Immunology, University of Illinois-College of Medicine, Chicago, IL, United States.
Mujeeb BasitDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Mirella SalvatoreDepartment of Medicine, Weill Cornell Medicine, New York, NY, United States.
Jerry A KrishnanBreathe Chicago Center, University of Illinois Chicago, Chicago, IL, United States.
Charles C KimVerily Life Sciences, South San Francisco, CA, United States.
Alaska Heart and Vascular Institute · USBaylor College of Medicine · USCedars-Sinai Medical Center · USCornell University · USLittle Company of Mary Hospital · USRush University Medical Center · USThe University of Texas Southwestern Medical Center · USUniversity of Arizona · USUniversity of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · US

Funding

Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
NCATS NIH HHS UL1 TR002384
6 · The paper itself

Abstract

Background: The understanding of Post-acute sequelae of SARS-CoV-2 infection (PASC) can be improved by longitudinal assessment of symptoms encompassing the acute illness period. To gain insight into the various disease trajectories of PASC, we assessed symptom evolution and clinical factors associated with the development of PASC over 3 months, starting with the acute illness period. Methods: We conducted a prospective cohort study to identify parameters associated with PASC. We performed cluster and case control analyses of clinical data, including symptomatology collected over 3 months following infection. Results: We identified three phenotypic clusters associated with PASC that could be characterized as remittent, persistent, or incident based on the 3-month change in symptom number compared to study entry: remittent (median; min, max: -4; -17, 3), persistent (-2; -14, 7), or incident (4.5; -5, 17) ( Conclusion: An incident disease phenotype characterized by symptoms that were absent during acute illness and the observed association with high dose steroids during acute illness have potential critical implications for preventing PASC.

Indexed as

COVID-19long COVIDPASCSARS-CoV-2symptom clusters

Identifiers

PMID37908849
PMCPMC10614284
OpenAlexW4387667151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.