Evidence map›Paper›PMID 37908807›Full record

ArticleRedox biochemistry and chemistry2023

Arsenic exposure and increased

Dorian M Cheff, Helena Skröder, Evana Akhtar, Qing Cheng, Matthew D Hall, Rubhana Raqib, Maria Kippler, Marie Vahter, Elias S J Arnér

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biochemistry and chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Dorian M CheffDivision of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE, 171 77, Stockholm, Sweden.
Helena SkröderUnit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE, 171 77, Stockholm, Sweden.
Evana AkhtarInternational Center for Diarrheal Disease Research, GPO Box 128, Dhaka, 1000, Bangladesh.
Qing ChengDivision of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE, 171 77, Stockholm, Sweden.
Matthew D HallEarly Translation Branch, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD, 20850, United States.
Rubhana RaqibInternational Center for Diarrheal Disease Research, GPO Box 128, Dhaka, 1000, Bangladesh.
Maria KipplerUnit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE, 171 77, Stockholm, Sweden.
Marie VahterUnit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE, 171 77, Stockholm, Sweden.
Elias S J ArnérDivision of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE, 171 77, Stockholm, Sweden.
Karolinska Institutet · SEInternational Centre for Diarrhoeal Disease Research · BDNational Institutes of Health · US

Funding

Screening for novel inhibitors of Glutathione Peroxidase 1 and 4ZIATR000418 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI HALL, MATTHEW · 2020 to 2025
$1.1M
Intramural NIH HHS ZIA TR000418
6 · The paper itself

Abstract

Toxic metal contaminants present in food and water have widespread effects on health and disease. Chalcophiles, such as arsenic, cadmium, and mercury, show a high affinity to selenium and exposure to these metals could have a modulating effect on enzymes dependent on selenocysteine in their active sites. The aim of this study was to assess the influence of these metals on the activity of the selenoprotein glutathione peroxidase 1 (GPX1) in erythrocytes of 100 children residing in rural Bangladesh, where drinking water often contains arsenic. GPX1 expression, as measured using high-throughput immunoblotting, showed little correlation with GPX activity (

Indexed as

ArsenicC-reactive proteinEnzymatic activityGlutathione peroxidaseOxidative stressSelenium

Identifiers

PMID37908807
PMCPMC10613583
OpenAlexW4387095236

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.