ArticleFrontiers in cellular and infection microbiology2023
Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results.
Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Pathogenesis exploration of lgG4-related disease: From the traditional central dogma and its remodeling perspective.Chinese medical journal · 2026Review
- IgG4-related disease has a specific intestinal microbiota signature.EBioMedicine · 2026Article
- Improving DirectLiNGAM for high-dimensional microbiome data: roots screening and eBIC based model selection.Frontiers in systems biology · 2026Article
- Gut microbiome alterations in IgG4-related ophthalmic disease.BMC microbiology · 2025Article
- Immunoglobulin G4-related disease requiring clinical attention: A case report and review of literature.World journal of gastroenterology · 2025Review
- IgG4-Related Disease: Emerging Roles of Novel Genetic Variants, Immune Cell Subsets and Therapeutic Targets.Allergy · 2025Review
- Factors related to elevated serum immunoglobulin G4 (IgG4) levels in a Japanese general population.Arthritis research & therapy · 2024Article
- Supplementation with Chinese herbal preparations protect the gut-liver axis of Hu sheep, promotes gut-liver circulation, regulates intestinal flora and immunity.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Immunoglobulin G4 (IgG4) is a member of the human immunoglobulin G (IgG) subclass, a protein involved in immunity to pathogens and the body's resistance system. IgG4-related diseases (IgG4-RD) are intractable diseases in which IgG4 levels in the blood are elevated, causing inflammation in organs such as the liver, pancreas, and salivary glands. IgG4-RD are known to be more prevalent in males than in females, but the etiology remains to be elucidated. This study was conducted to investigate the relationship between gut microbiota (GM) and serum IgG4 levels in the general population. Methods: In this study, the relationship between IgG4 levels and GM evaluated in male and female groups of the general population using causal inference. The study included 191 men and 207 women aged 40 years or older from Shika-machi, Ishikawa. GM DNA was analyzed for the 16S rRNA gene sequence using next-generation sequencing. Participants were bifurcated into high and low IgG4 groups, depending on median serum IgG4 levels. Results: ANCOVA, Tukey's HSD, linear discriminant analysis effect size, least absolute shrinkage and selection operator logistic regression model, and correlation analysis revealed that Discussion: This differential impact of the GM on IgG4 levels based on sex is a novel and intriguing finding.
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Registered trials
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