Evidence map›Paper›PMID 37908563›Full record

ArticleBurns & trauma2023

Álvaro Sierra-Sánchez, Brice Magne, Etienne Savard, Christian Martel, Karel Ferland, Martin A Barbier, Anabelle Demers, Danielle Larouche, Salvador Arias-Santiago, Lucie Germain

Open access · diamondAbstract read
In one paragraph

Article in Burns & trauma, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Álvaro Sierra-SánchezLOEX Tissue Engineering Laboratory and Department of Surgery, Faculty of Medicine, Université Laval, 1401 18e rue, Québec (Québec) G1J 1Z4, Canada.ORCID https://orcid.org/0000-0003-4511-408X
Brice MagneLOEX Tissue Engineering Laboratory and Department of Surgery, Faculty of Medicine, Université Laval, 1401 18e rue, Québec (Québec) G1J 1Z4, Canada.ORCID https://orcid.org/0000-0001-5052-1144
Etienne SavardLOEX Tissue Engineering Laboratory and Department of Surgery, Faculty of Medicine, Université Laval, 1401 18e rue, Québec (Québec) G1J 1Z4, Canada.ORCID https://orcid.org/0000-0002-3664-3601
Christian MartelLOEX Tissue Engineering Laboratory and Department of Surgery, Faculty of Medicine, Université Laval, 1401 18e rue, Québec (Québec) G1J 1Z4, Canada.ORCID https://orcid.org/0000-0001-7952-4330
Karel FerlandLOEX Tissue Engineering Laboratory and Department of Surgery, Faculty of Medicine, Université Laval, 1401 18e rue, Québec (Québec) G1J 1Z4, Canada.ORCID https://orcid.org/0000-0003-0715-3854
Martin A BarbierLOEX Tissue Engineering Laboratory and Department of Surgery, Faculty of Medicine, Université Laval, 1401 18e rue, Québec (Québec) G1J 1Z4, Canada.ORCID https://orcid.org/0000-0002-4298-4234
Anabelle DemersLOEX Tissue Engineering Laboratory and Department of Surgery, Faculty of Medicine, Université Laval, 1401 18e rue, Québec (Québec) G1J 1Z4, Canada.ORCID https://orcid.org/0000-0003-4382-0589
Danielle LaroucheLOEX Tissue Engineering Laboratory and Department of Surgery, Faculty of Medicine, Université Laval, 1401 18e rue, Québec (Québec) G1J 1Z4, Canada.ORCID https://orcid.org/0000-0003-4900-1832
Salvador Arias-SantiagoUnidad de Producción Celular e Ingeniería Tisular (UPCIT), Virgen de las Nieves University Hospital, ibs. GRANADA, Andalusian Network for the design and translation of Advanced Therapies, Av. de las Fuerzas Armadas, Nº2, 4ª Planta Ed. de Gobierno, 18014, Granada, Spain.ORCID https://orcid.org/0000-0002-4186-1435
Lucie GermainLOEX Tissue Engineering Laboratory and Department of Surgery, Faculty of Medicine, Université Laval, 1401 18e rue, Québec (Québec) G1J 1Z4, Canada.ORCID https://orcid.org/0000-0001-8883-6491
Université Laval · CAInstituto de Investigación Biosanitaria de Granada · ESUniversidad de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The aim of this Methods: Fibroblasts and keratinocytes from three humans were extracted from skin biopsies (N = 3) and cells from the same donor were used to produce both hbTESS models. For SASS manufacture, keratinocytes were seeded over three self-assembled dermal sheets comprising fibroblasts and the extracellular matrix they produced (n = 12), while for HPSS production, keratinocytes were cultured over hydrogels composed of fibroblasts embedded in either plasma as unique biomaterial (Fibrin), plasma combined with hyaluronic acid (Fibrin-HA) or plasma combined with collagen (Fibrin-Col) (n/biomaterial = 9). The production time was 46-55 days for SASSs and 32-39 days for HPSSs. Substitutes were characterized by histology, mechanical testing, PrestoBlue™-assay, immunofluorescence (Ki67, Keratin (K) 10, K15, K19, Loricrin, type IV collagen) and Western blot (type I and IV collagens). Results: The SASSs were more resistant to tensile forces ( Conclusions: This study demonstrates, for the first time, that both hbTESS models present similar

Indexed as

BiomaterialBurnFibrinHuman plasmaSelf-assemblySkin substituteTissue engineering

Identifiers

PMID37908563
PMCPMC10615253
OpenAlexW4388110218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.