ArticleRadiology. Cardiothoracic imaging2023
Impact of Coronary CT Angiography-derived Fractional Flow Reserve on Downstream Management and Clinical Outcomes in Individuals with and without Diabetes.
Registry-linked trialAbstract read
In one paragraph
Article in Radiology. Cardiothoracic imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02499679 (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary CarE), which is not on this map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessing Diagnostic Value of Non-invasive FFRCT in Coronary CarE (ADVANCE)
Who cites it
10 citing papers in PubMed.
- FFR-CT: Technical Advances and Implementation in Clinical Practice.Journal of imaging · 2026Review
- A Pathophysiology-Oriented Imaging Phenotype Framework for Nonobstructive Coronary Artery Disease.Journal of cardiovascular development and disease · 2026Article
- CT-derived fractional flow reserve combined with atherosclerotic extent to determine long-term outcomes in diabetic patients with coronary artery disease.Journal of geriatric cardiology : JGC · 2026Article
- Long-term prognostic value of the CT-derived fractional flow reserve combined with atherosclerotic burden in patients with non-obstructive coronary artery disease.European radiology · 2025Article
- Incremental prognostic value of ischemic score quantified by stress dynamic CT myocardial perfusion in patients with and without diabetes mellitus.Scientific reports · 2025Article
- Computed Tomography and Coronary Plaque Analysis.Tomography (Ann Arbor, Mich.) · 2025Review
- Prognostic Significance of Computed Tomography-Derived Fractional Flow Reserve for Long-Term Outcomes in Individuals With Coronary Artery Disease.Journal of the American Heart Association · 2025Article
- The Role of Coronary Computed Tomography Angiography in the Diagnosis, Risk Stratification, and Management of Patients with Diabetes and Chest Pain.Reviews in cardiovascular medicine · 2024Review
- Review
- Coronary CT Angiography with CT Fractional Flow Reserve in Individuals with and without Diabetes Mellitus: Is It Time to Treat Patients the Same?Radiology. Cardiothoracic imaging · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Gaurav S GulsinFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-1740-9270
Georgios TzimasFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).
Kenneth-Royce HolmesFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).
Hidenobu TakagiFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-3071-5803
Stephanie L SellersFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-3539-5730
Philipp BlankeFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).
Lynne M H KoweekFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0001-9990-3397
Bjarne L NørgaardFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-4758-7203
Jesper JensenFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).
Mark G RabbatFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).
Gianluca PontoneFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).
Timothy A FairbairnFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0003-1491-6231
Kavitha M ChinnaiyanFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-1337-826X
Pamela S DouglasFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0001-9876-4049
Whitney HueyFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0009-0000-1976-958X
Hitoshi MatsuoFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-1571-6533
Niels P R SandFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).
Koen NiemanFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-8312-0598
Jeroen J BaxFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0001-7368-0500
Tetsuya AmanoFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-6833-3675
Tomohiro KawasakiFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-4795-7745
Takashi AkasakaFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0003-3020-9369
Campbell RogersFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0003-3955-7650
Daniel S BermanFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-3793-9578
Manesh R PatelFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-2393-0855
Bernard De BruyneFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).
Sarah MullenFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-1387-8934
Jonathon A LeipsicFrom the Department of Medicine and Radiology, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6T 1Z3 (G.S.G., G.T., K.R.H., H.T., S.L.S., P.B., J.A.L.); Department of Cardiovascular Sciences, University of Leicester and the NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK (G.S.G.); Department of Heart Vessels, Cardiology Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (G.T.); Centre for Heart Lung Innovation, University of British Columbia and St Paul's Hospital, Vancouver, BC, Canada (S.L.S., J.A.L.); Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.M.H.K., M.R.P.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.J.); Department of Cardiology, Loyola University of Chicago, Chicago, Ill; (M.G.R.); Department of Cardiology, Edward Hines Jr VA Hospital, Hines, Ill (M.G.R.); Department of Cardiology, Centro Cardiologico Monzino, Milan, Italy (G.P.); Department of Cardiology, University of Liverpool, Liverpool Heart and Chest Hospital, Liverpool, UK (T.A.F.); Department of Cardiology, Beaumont Health, Royal Oak, Mich (K.M.C.); Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (P.S.D.); Department of Cardiology, Gifu Heart Center, Gifu, Japan (H.M.); Cardiac Research Unit, Institute of Regional Health Research, University Hospital of SouthWest DK, University of Southern Denmark, Odense, Denmark (N.P.R.S.); Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Department of Cardiology, Aichi Medical University, Aichi, Japan (T. Amano); Cardiovascular Center, Shin Koga Hospital, Fukuoka, Japan (T.K.); Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan (T. Akasaka); HeartFlow Inc, Redwood City, Calif (W.H., C.R., S.M.); Division of Nuclear Imaging, Department of Imaging, Cedars-Sinai Heart Institute, Los Angeles, Calif (D.S.B.); and Cardiovascular Center Aalst, OLV-Clinic, Aalst, Belgium (B.D.B.).ORCID 0000-0002-6133-8334
Funding
British Heart Foundation FS/TF/21/33008
Abstract
Purpose: To compare the clinical use of coronary CT angiography (CCTA)-derived fractional flow reserve (FFR) in individuals with and without diabetes mellitus (DM). Materials and Methods: This secondary analysis included participants (enrolled July 2015 to October 2017) from the prospective, multicenter, international The Assessing Diagnostic Value of Noninvasive CT-FFR in Coronary Care (ADVANCE) registry (ClinicalTrials.gov identifier, NCT02499679) who were evaluated for suspected coronary artery disease (CAD), with one or more coronary stenosis ≥30% on CCTA images, using CT-FFR. CCTA and CT-FFR findings, treatment strategies at 90 days, and clinical outcomes at 1-year follow-up were compared in participants with and without DM. Results: The study included 4290 participants (mean age, 66 years ± 10 [SD]; 66% male participants; 22% participants with DM). Participants with DM had more obstructive CAD (one or more coronary stenosis ≥50%; 78.8% vs 70.6%, Conclusion: Both anatomic CCTA findings and CT-FFR demonstrated a more complex pattern of CAD in participants with versus without DM. Rates of treatment reclassification were similar regardless of the presence of DM, and DM was not an adverse prognostic indicator when adjusted for diameter stenosis and CT-FFR.Clinical trial registration no. NCT 02499679
Indexed as
Coronary Artery DiseaseCT AngiographyDiabetes MellitusFractional Flow Reserve
Identifiers
What OpenQuestion holds
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Registered trials
NCT02499679ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.