Evidence map›Paper›PMID 37908322›Full record

ArticleNeurotrauma reports2023

Plasma von Willebrand Factor Is Elevated Hyperacutely After Mild Traumatic Brain Injury.

Rachel Thomas, Cillian E Lynch, Jeff Debad, Christopher Campbell, Onyinyechi Chidomere, Joseph Kilianski, Kan Ding, Christopher Madden, Danielle K Sandsmark, Ramon Diaz-Arrastia and 1 more

Open access · goldAbstract read
In one paragraph

Article in Neurotrauma reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Rachel ThomasDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Cillian E LynchDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Jeff DebadMeso Scale Diagnostics, LLC, Rockville, Maryland, USA.
Christopher CampbellMeso Scale Diagnostics, LLC, Rockville, Maryland, USA.
Onyinyechi ChidomereDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Joseph KilianskiDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Kan DingDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Christopher MaddenDepartment of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Danielle K SandsmarkDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Ramon Diaz-ArrastiaDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Joshua W GatsonDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
The University of Texas Southwestern Medical Center · USUniversity of Pennsylvania · USMeso Scale Discovery (United States) · US

Funding

Natural History of Traumatic Microvascular InjuryK23NS104239 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SANDSMARK, DANIELLE KAYE · 2017 to 2021
$929k
NINDS NIH HHS K23 NS104239
6 · The paper itself

Abstract

Each year in the United States, ∼2.7 million persons seek medical attention for traumatic brain injury (TBI), of which ∼85% are characterized as being mild brain injuries. Many different cell types in the brain are affected in these heterogeneous injuries, including neurons, glia, and the brain vasculature. Efforts to identify biomarkers that reflect the injury of these different cell types have been a focus of ongoing investigation. We hypothesized that von Willebrand factor (vWF) is a sensitive biomarker for acute traumatic vascular injury and correlates with symptom severity post-TBI. To address this, blood was collected from professional boxing athletes (

Indexed as

biomarkertraumatraumatic brain injury (TBI)von Willebrand factor (vWF)

Identifiers

PMID37908322
PMCPMC10615084
OpenAlexW4387541455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.