ArticleJGH open : an open access journal of gastroenterology and hepatology2023
Esophageal squamous papilloma: Literature review and case-control retrospective study with histopathological exam of human papillomavirus.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 6 citations in OpenAlex.
- Goltz Syndrome With Large Esophageal Squamous Papillomas-A Unique Cause of Dysphagia Amenable to Endoscopic Treatment.ACG case reports journal · 2026Article
- The Controversial Link Between Human Papillomavirus Infection and Esophageal Health: An Exploratory Translational Study.Pathogens (Basel, Switzerland) · 2026Article
- Pan-esophageal squamous papillomatosis with high grade dysplasia managed with endoscopic submucosal dissection.Endoscopy · 2025Article
- Esophageal Squamous Papilloma and Papillomatosis: Current Evidence of HPV Involvement and Malignant Potential.Cancers · 2025Review
- Squamous Papilloma of the Esophagus in a Patient With Refractory Gastroesophageal Reflux Disease.Cureus · 2025Article
- Esophageal Squamous Cell Papilloma: A Case Report of Controversial Rare Benign Esophageal Lesion.Middle East journal of digestive diseases · 2025Article
- Novel Endoscopic Findings of Lesions with a Short White Hair-like Appearance in the Lower Esophagus.Internal medicine (Tokyo, Japan) · 2024Article
- Tentacular-Type Esophageal Papilloma.ACG case reports journal · 2024Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aim: Esophageal squamous papilloma (ESP) is a benign growth in the esophagus with unknown malignant potential. The mechanism underlying ESP formation is unknown, but human papillomavirus (HPV) infection has been proposed as a potential etiology. We sought to investigate the clinical characteristic of ESP in our population, review the current literature, and highlight the role of HPV. Methods: This is a retrospective case-control study conducted at two referral centers. We selected the ESP population by free-text search in the pathology department database and selected controls randomly from the general endoscopy population. Immunostains were used to evaluate ESP tissue for HPV. Results: Between January 2016 and December 2021, we identified 66 patients with ESP, with a prevalence of 0.72%. ESP patients were younger, with a median age of 52 years ( Conclusions: We observed a higher prevalence of ESP compared to previous studies. The formation of ESP is multifactorial and partially explained by HPV infection in selected populations. The malignant potential of ESP is low but not negligible.
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Registered trials
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