Evidence map›Paper›PMID 37908196›Full record

ArticleBioelectromagnetics

Investigation of the mechanisms for wireless nerve stimulation without active electrodes.

Luke A Smith, Jaedon D Bem, Xiaojing Lv, Antonio Lauto, Ashour Sliow, Zhiyuan Ma, David A Mahns, Carolyn Berryman, Mark R Hutchinson, Christophe Fumeaux and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioelectromagnetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luke A SmithSchool of Electrical and Electronic Engineering, University of Adelaide, Adelaide, Australia.
Jaedon D BemSchool of Electrical and Electronic Engineering, University of Adelaide, Adelaide, Australia.
Xiaojing LvSchool of Electrical and Electronic Engineering, University of Adelaide, Adelaide, Australia.
Antonio LautoSchool of Science, Western Sydney University, Penrith, New South Wales, Australia.
Ashour SliowSchool of Science, Western Sydney University, Penrith, New South Wales, Australia.
Zhiyuan MaSchool of Medicine, Western Sydney University, Penrith, New South Wales, Australia.
David A MahnsSchool of Medicine, Western Sydney University, Penrith, New South Wales, Australia.
Carolyn BerrymanSchool of Biomedicine, University of Adelaide, Adelaide, South Australia, Australia.
Mark R HutchinsonAdelaide Medical School, Institute of Photonics and Advanced Sensing, University of Adelaide, Adelaide, South Australia, Australia.
Christophe FumeauxSchool of Electrical and Electronic Engineering, University of Adelaide, Adelaide, Australia.
Giuseppe C TettamanziDiscipline of Materials Engineering, School of Chemical Engineering, University of Adelaide, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-3209-0632

Funding

Australian Research Council (ARC), Future Fellowship FT180100565Centre for Nanoscale Bio-Photonics (CNBP) CE140100003National Health and Medical Research Council, Early Career Fellowship 1127155
6 · The paper itself

Abstract

Electric-field stimulation of neuronal activity can be used to improve the speed of regeneration for severed and damaged nerves. Most techniques, however, require invasive electronic circuitry which can be uncomfortable for the patient and can damage surrounding tissue. A recently suggested technique uses a graft-antenna-a metal ring wrapped around the damaged nerve-powered by an external magnetic stimulation device. This technique requires no electrodes and internal circuitry with leads across the skin boundary or internal power, since all power is provided wirelessly. This paper examines the microscopic basic mechanisms that allow the magnetic stimulation device to cause neural activation via the graft-antenna. A computational model of the system was created and used to find that under magnetic stimulation, diverging electric fields appear at the metal ring's edges. If the magnetic stimulation is sufficient, the gradients of these fields can trigger neural activation in the nerve. In-vivo measurements were also performed on rat sciatic nerves to support the modeling finding that direct contact between the antenna and the nerve ensures neural activation given sufficient magnetic stimulation. Simulations also showed that the presence of a thin gap between the graft-antenna and the nerve does not preclude neural activation but does reduce its efficacy.

Indexed as

NeuronsSciatic NerveAnimalsElectric StimulationElectrodesHumansMagnetsRatscomputational electromagneticselectromagnetic stimulationgraft-antennamagnetostaticsnerve stimulationneural activation

Identifiers

PMID37908196
PMCPMC10947236

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.