Evidence map›Paper›PMID 37907771›Full record

ReviewCurrent urology reports2023

The Potential Role of Persister Cells in Urinary Tract Infections.

Butool Durrani, Ashu Mohammad, Bernardita M Ljubetic, Amy D Dobberfuhl

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current urology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Bacterial persisters: molecular mechanisms and therapeutic development.Signal transduction and targeted therapy · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Butool DurraniDepartment of Internal Medicine, Aga Khan University Hospital, National Stadium Rd, Karachi, Karachi City, Pakistan.ORCID http://orcid.org/0009-0003-4401-3903
Ashu MohammadDepartment of Urology, Center for Academic Medicine, Stanford University School of Medicine, 453 Quarry Road, Urology-5656, Palo Alto, CA, 94304, USA.ORCID http://orcid.org/0000-0001-6494-720X
Bernardita M LjubeticDepartment of Urology, Center for Academic Medicine, Stanford University School of Medicine, 453 Quarry Road, Urology-5656, Palo Alto, CA, 94304, USA.ORCID http://orcid.org/0000-0001-7367-5939
Amy D DobberfuhlDepartment of Urology, Center for Academic Medicine, Stanford University School of Medicine, 453 Quarry Road, Urology-5656, Palo Alto, CA, 94304, USA. adobber@stanford.edu.ORCID http://orcid.org/0000-0003-3451-3878
Stanford University · USAga Khan University Hospital · PKStanford Medicine · US

Funding

Signal integration by specialized mesenchyme in urothelial homeostasis and Interstitial Cystitis / Bladder Pain SyndromeR01DK134989 · NIDDK · STANFORD UNIVERSITY · PI BEACHY, PHILIP A · 2022 to 2025
$3.0M
Validation of a Neurogenic Bladder Management Solution to Promote Independence and Reduce Long-Term Morbidity for Patients Unable to Perform Intermittent CatheterizationR44DK127580 · NIDDK · CRM MEDICAL DEVICES, INC. · PI ELLIOTT, CHRISTOPHER, EVERSULL, CHRISTIAN S · 2022 to 2023
$1.5M
NIH HHS NIH 1R01CA249807NIH HHS NIH 1R01DK134989NIH HHS NIH 2R44DK127580
6 · The paper itself

Abstract

purpose of reviewThis review explores the role of persister cells in urinary tract infections (UTIs). UTIs are one of the most common bacterial infections, affecting millions of people worldwide. Persister cells are a subpopulation of bacteria with dormant metabolic activity which allows survival in the presence of antibiotics. RECENT

findingsThis review summarizes recent research on the pathogenesis of persister cell formation in UTIs, the impact of persister cells on the effectiveness of antibiotics, the challenges they pose for treatment, and the need for new strategies to target these cells. Furthermore, this review examines the current state of research on the identification and characterization of persister cells in UTIs, as well as the future directions for investigations in this field. This review highlights the importance of understanding the role of persister cells in UTIs and the potential impact of targeting these cells in the development of new treatments.

Indexed as

Bacterial InfectionsUrinary Tract InfectionsAnti-Bacterial AgentsHumansAnti-Bacterial AgentsAntibiotic tolerance / resistanceBiofilmCystitisUrinary tract infections / diagnosis

Identifiers

PMID37907771
OpenAlexW4388135827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.