ArticleClinical oral investigations2023
Causal relationship between psychiatric traits and temporomandibular disorders: a bidirectional two-sample Mendelian randomization study.
Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Pain-Affective Disorder Comorbidity in the Temporomandibular Disorders: From Mechanistic Insights to Clinical Management.Neuroscience bulletin · 2026Review
- A Comprehensive Mendelian Randomization Study of Bidirectional Causal Relationships Between Pain and Mental Disorders.Journal of pain research · 2026Article
- Genetic prediction of blood metabolites and causal relationships with pain associated with temporomandibular disorders: a Mendelian randomization study.Journal of oral & facial pain and headache · 2025Article
- Temporomandibular disorders and mental health: shared etiologies and treatment approaches.The journal of headache and pain · 2025Review
- Mechanisms for Orofacial Pain: Roles of Immunomodulation, Metabolic Reprogramming, Oxidative Stress and Epigenetic Regulation.Biomedicines · 2025Review
- The potential association between sedentary behaviors and risk of temporomandibular disorders: evidence from Mendelian randomization analysis.Journal of oral & facial pain and headache · 2024Article
- Exploring the causal effects of sleep characteristics on TMD-related pain: a two-sample Mendelian randomization study.Clinical oral investigations · 2024Article
- Is there a causal association between temporomandibular disorders and COVID-19 risk? A genetic instrumental variables analysis.Journal of oral & facial pain and headache · 2024Article
- Major depressive disorder elevates the risk of dentofacial deformity: a bidirectional two-sample Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Assessing the Causal Relationship Between Immune Cells and Temporomandibular Related Pain by Bi‑Directional Mendelian Randomization Analysis.Journal of pain research · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study was to investigate the causal relationship between temporomandibular disorders (TMD) and psychiatric disorders by Mendelian randomization (MR) analysis. MATERIALS AND
methodsA two-sample bidirectional MR analysis was adopted to systematically explore the causal relationship between TMD and eight psychiatric traits, including anxiety disorder (AD), panic disorder (PD), major depressive disorder (MDD), neuroticism, attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BIP), and schizophrenia (SCZ). Inverse variance weighted (IVW), weighted median, and MR-Egger regression were used in my study. Furthermore, we also performed three sensitivity analyses to illustrate the reliability of the analysis.
resultsTwo psychiatric traits have risk effects on TMD: PD (OR = 1.118, 95% CI: 1.047-1.194, P = 8.161 × 10
conclusionsOur two-sample MR study has provided further evidence of PD and MDD being related to a higher risk of TMD. CLINICAL RELEVANCE: These findings highlight the importance of closely monitoring mental traits during future TMD treatments to prevent an increased risk of TMD.
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