SynthesisBMJ mental health2023
Relationship between severe mental illness and physical multimorbidity: a meta-analysis and call for action.
Synthesis in BMJ mental health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Evaluating the impact of pharmacists in outpatient mental health settings: a systematic review.International journal of clinical pharmacy · 2026Pooled it
- Psychosocial and Demographic Factors Associated with Physical Multimorbidity in Severe Mental Illness: A Systematic Review.Schizophrenia bulletin · 2026Pooled it
- The prevalence of mental health-related multimorbidity during pregnancy: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Improvements in health-related quality of life with esketamine nasal spray versus quetiapine extended release.European psychiatry : the journal of the Association of European Psychiatrists · 2025Trial
- Identifying and Addressing Unmet Needs in Dementia: The Role of Care Access and Psychosocial Support.International journal of geriatric psychiatry · 2025Trial
- Dynamical system modeling in schizophrenia: a narrative review of computational psychiatry frameworks.Dialogues in clinical neuroscience · 2026Review
- Assessing the Needs of Community Mental Health Service Users with Chronic Physical Health Conditions: A Cross-Sectional Study.Community mental health journal · 2026Article
- FOR-HEALTH: study protocol for a randomized controlled feasibility trial of Structured Health Dialogues to improve lifestyle habits and metabolic health in forensic psychiatric inpatients.Pilot and feasibility studies · 2026Article
- Socioeconomic Position and Somatic Comorbidity in Mental Disorders.Acta psychiatrica Scandinavica · 2026Article
- Health Care Professionals' Perspectives on Conversational Mental Health Chatbots: Protocol for a Systematic Review.JMIR research protocols · 2026Article
- Associations between lifestyle, genetic liability for severe mental illness and risk of incident somatic illnesses.Translational psychiatry · 2026Article
- Integrated care programmes for severe mental illnesses and comorbid physical health disorders: the EU-MIND umbrella review to inform future actions in Europe.EClinicalMedicine · 2026Review
- Mapping genetic convergence across brain structure, mental health, and cardiometabolic disease.Communications medicine · 2026Article
- Implementing Community-Based Psychosocial Interventions for Adults with Severe Mental Illness in High-Income Countries: A Rapid Scoping Review.Community mental health journal · 2026Article
- Effect of an implementation support program aimed at an evidence-based physical healthcare model for patients with severe mental illness.BMC psychiatry · 2026Article
- Sociodemographic, academic, and health-related factors associated with antidepressant use among university and higher education students: a scoping review.Social psychiatry and psychiatric epidemiology · 2026Review
- Characterizing Infectious Disease Mortality in Severe Mental Illness: A Retrospective Matched Cohort Study.Schizophrenia bulletin · 2026Article
- Tobacco cessation intervention for individuals with severe mental illness in Bangladesh, India, and Pakistan: protocol for a multi-country feasibility randomised controlled trial (SCIMITAR-SA).Contemporary clinical trials communications · 2026Article
- Advancing Inclusive Design Practice for Queer Youth Using Digital Technologies for Mental Health.The Medical journal of Australia · 2026Article
- Evaluating the cost-effectiveness of Everyday Life Rehabilitation (ELR) for individuals with serious mental illness in supported accommodation.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
backgroundPeople with severe mental illness (SMI) have a higher prevalence of several chronic physical health conditions, and the prevalence of physical multimorbidity is expected to rise. The aim of this study was to assess the strength of the association between SMI and physical multimorbidity. STUDY SELECTION AND ANALYSIS: We systematically searched PubMed/Medline, Scopus, Embase, Web of Science, PsycINFO and the behavioural sciences collection databases, from inception to 31 January 2023, for studies that investigated the association between SMI and physical multimorbidity. Humans of any age either clinically diagnosed and/or currently receiving treatment for SMI, specified as schizophrenia (and related psychotic disorders), bipolar disorder and psychotic depression, were eligible. Data from studies selected for inclusion were converted into ORs, with a subsequent meta-analysis conducted.
findingsWe included 19 studies with a total of 194 123 patients with SMI with different diagnoses and drawn from the general population. The pooled OR for physical multimorbidity in people with versus without SMI was 1.84 (95% CI 1.33 to 2.54), with the analysis indicating a high level of heterogeneity (98.38%). The other 15 studies included in the systematic review for which it was not possible to conduct a meta-analysis showed strong associations between SMI and physical multimorbidity.
conclusionsThe current evidence highlights the link between SMI and physical multimorbidity. A multidisciplinary approach is now urgent to develop the best models of services tailored to patients with SMI with physical multimorbidities to improve physical, mental and social outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.