ArticleJournal of neuroradiology = Journal de neuroradiologie2024
Multimodal assessment of brain fluid clearance is associated with amyloid-beta deposition in humans.
Article in Journal of neuroradiology = Journal de neuroradiologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Evaluating early vs. late static SUVR windows of [¹⁸F]MK-6240 tau PET in Alzheimer disease: a head-to-head comparison study.European journal of nuclear medicine and molecular imaging · 2026Article
- Increased MRI-derived parenchymal cerebral spinal fluid mapping in untreated obstructive sleep apnea patients.Neurobiology of disease · 2026Article
- G-ALPS: An index for evaluating cognitive decline and aging using diffusion tensor imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Worse visibility of deep medullary veins is associated with larger lateral ventricles but not with cortical thickness.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026Article
- Glymphatic system dysfunction in pediatric growth hormone deficiency evidenced by multiple MRI metrics.Quantitative imaging in medicine and surgery · 2026Article
- Article
- DTI-ALPS index-assessed glymphatic dysfunction mediates Alzheimer's cognitive decline via amyloid-β-dependent pathways: multimodal PET/MRI study.European journal of nuclear medicine and molecular imaging · 2025Article
- Decreased quantitative transport mapping velocity in the middle cerebral artery-supplied temporal lobe in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Interrater and intrarater reliability of aqueduct CSF flow parameters measured by phase-contrast MRI in healthy adults.Quantitative imaging in medicine and surgery · 2025Article
- Synergistic effects of plasma S100B and MRI measures of cerebrovascular disease on cognition in older adults.GeroScience · 2025Article
- PET Imaging of Neurofluids.Neuroimaging clinics of North America · 2025Review
- Assessment of glymphatic function and white matter integrity in children with autism using multi-parametric MRI and machine learning.European radiology · 2025Article
- Multimodal DTI-ALPS and hippocampal microstructural signatures unveil stage-specific pathways in Alzheimer's disease progression.Frontiers in aging neuroscience · 2025Article
- Region-informed machine learning model for choroid plexus segmentation in Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Glymphatic system dysfunction in cerebral infarction: advances and perspectives based on DTI-derived ALPS measures.American journal of translational research · 2025Review
- Brain glymphatic fluid mapping in Alzheimer's disease: a human MRI and PET study.Brain communications · 2025Article
- Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Review
- Validating the accuracy of real-time phase-contrast MRI and quantifying the effects of free breathing on cerebrospinal fluid dynamics.Fluids and barriers of the CNS · 2024Article
- Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Diffusion Tensor Imaging Along Perivascular Spaces (DTI-ALPS) to Assess Effects of Age, Sex, and Head Size on Interstitial Fluid Dynamics in Healthy Subjects.Journal of Alzheimer's disease reports · 2024Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe present study investigates a multimodal imaging assessment of glymphatic function and its association with brain amyloid-beta deposition.
methodsTwo brain CSF clearance measures (vCSF and DTI-ALPS) were derived from dynamic PET and MR diffusion tensor imaging (DTI) for 50 subjects, 24/50 were Aβ positive (Aβ+). T1W, T2W, DTI, T2FLAIR, and
resultsSample demographics (N=50) include 20 males and 30 females with a mean age of 69.30 (sd=8.55). Our results show that the combination of vCSF and ALPS associates with Aβ deposition (p < 0.05, R
conclusionThe regression model with both vCSF and DTI-ALPS is better associated with brain Aβ deposition. These two independent brain clearance measures may better explain the variation in Aβ deposition than either term individually. Our results suggest that vCSF and DTI-ALPS reflect complementary aspects of brain clearance functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.