Evidence map›Paper›PMID 37906416›Full record

ReviewFood and environmental virology2023

Antiviral Natural Products, Their Mechanisms of Action and Potential Applications as Sanitizers and Disinfectants.

Stephanie A Boone, M Khalid Ijaz, Kelly R Bright, Norma Patricia Silva-Beltran, Raymond W Nims, Julie McKinney, Charles P Gerba

Abstract readReview
PubMed Publisher
In one paragraph

Review in Food and environmental virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stephanie A BooneDepartment of Environmental Science, University of Arizona, Tucson, AZ, USA. sboone@arizona.edu.
M Khalid IjazGlobal Research & Development for Lysol and Dettol, Reckitt Benckiser LLC, Montvale, NJ, USA.
Kelly R BrightDepartment of Environmental Science, University of Arizona, Tucson, AZ, USA.
Norma Patricia Silva-BeltranDepartment of Environmental Science, University of Arizona, Tucson, AZ, USA.
Raymond W NimsSyner-G Biopharma, Boulder, CO, USA.
Julie McKinneyGlobal Research & Development for Lysol and Dettol, Reckitt Benckiser LLC, Montvale, NJ, USA.
Charles P GerbaDepartment of Environmental Science, University of Arizona, Tucson, AZ, USA.
University of Arizona · USReckitt Benckiser (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant extracts, natural products and plant oils contain natural virucidal actives that can be used to replace active ingredients in commercial sanitizers and disinfectants. This review focuses on the virucidal mechanisms of natural substances that may exhibit potential for indoor air and fomite disinfection. Review of scientific studies indicates: (1) most natural product studies use crude extracts and do not isolate or identify exact active antiviral substances; (2) many natural product studies contain unclear explanations of virucidal mechanisms of action; (3) natural product evaluations of virucidal activity should include methods that validate efficacy under standardized disinfectant testing procedures (e.g., carrier tests on applicable surfaces or activity against aerosolized viruses, etc.). The development of natural product disinfectants requires a better understanding of the mechanisms of action (MOA), chemical profiles, compound specificities, activity spectra, and the chemical formulations required for maximum activity. Combinations of natural antiviral substances and possibly the addition of synthetic compounds might be needed to increase inactivation of a broader spectrum of viruses, thereby providing the required efficacy for surface and air disinfection.

Indexed as

Biological ProductsDisinfectantsVirusesAntiviral AgentsDisinfectionAntiviral AgentsBiological ProductsDisinfectantsAntiviralDisinfectantsMechanism of actionNatural plant productsSanitizersViruses

Identifiers

PMID37906416
OpenAlexW4388042064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.