ArticleRadiology2023
Brain Growth Charts for Quantitative Analysis of Pediatric Clinical Brain MRI Scans with Limited Imaging Pathology.
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Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed.
- Normative modeling for quantitative brain MRI phenotyping and biomarker discovery for pediatric leukodystrophies.medRxiv : the preprint server for health sciences · 2026Article
- Brain charts for neuroanatomical sex differences across the human lifespan.bioRxiv : the preprint server for biology · 2026Article
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- Article
- Charting Brain Structure in 22q11.2 Deletion Syndrome with Clinical Neuroimaging.medRxiv : the preprint server for health sciences · 2026Article
- Reference Trajectories of Extra-Axial Cerebrospinal Fluid during Childhood and Adolescence Defined in a Clinically Acquired MRI Dataset.Radiology. Artificial intelligence · 2026Article
- Leveraging electronic health record data for precision medicine insights: the precision medicine registry at NYU Langone Health.npj health systems · 2026Article
- Paramagnetic Rim Lesions in Pediatric Multiple Sclerosis and Their Association With Brain Tissue Atrophy.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- White Matter Bundle Reconstruction From Single-Shell Diffusion Magnetic Resonance Imaging: Test-Retest Reliability and Predictive Capability Across Orientation Distribution Function Reconstruction Methods.Human brain mapping · 2025Article
- Systematic protocol to identify 'clinical controls' for paediatric neuroimaging research from clinically acquired brain MRIs.BMJ open · 2025Article
- Article
- A systematic protocol to identify "clinical controls" for pediatric neuroimaging research from clinically acquired brain MRIs.bioRxiv : the preprint server for biology · 2025Article
- Charting structural brain asymmetry across the human lifespan.bioRxiv : the preprint server for biology · 2025Article
- Subgrouping autism and ADHD based on structural MRI population modelling centiles.Molecular autism · 2025Article
- Empowering Data Sharing in Neuroscience: A Deep Learning Deidentification Method for Pediatric Brain MRIs.AJNR. American journal of neuroradiology · 2025Article
- Variability Rather Than Means? Harnessing the Adversary to Advance Precision Psychiatry.The American journal of psychiatry · 2025Article
- From Scanner to Science: Reusing Clinically Acquired Medical Images for Research.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025Article
- Automatic segmentation and quantitative analysis of brain CT volume in 2-year-olds using deep learning model.Frontiers in neurology · 2025Article
- Elucidation of Brain Morphogenesis Using Quantitative Brain Magnetic Resonance Imaging in Children.Pediatrics international : official journal of the Japan Pediatric SocietyReview
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Authors and funding
27 authors.
Jenna M SchabdachFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0003-3923-5846
J Eric SchmittFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.
Susan SotardiFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.
Arastoo VossoughFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0003-1346-427X
Savvas AndronikouFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0002-1015-9790
Timothy P RobertsFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.
Hao HuangFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0002-9103-4382
Viveknarayanan PadmanabhanFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.
Alfredo Ortiz-RosaFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.
Margaret GardnerFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0002-4498-0827
Sydney CovitzFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0002-7430-4125
Saashi A BedfordFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0002-0491-5342
Ayan S MandalFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0002-0780-3864
Barbara H ChaiyachatiFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0001-7324-6245
Simon R WhiteFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0001-8642-7037
Edward BullmoreFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.
Richard A I BethlehemFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0002-0714-0685
Russell T ShinoharaFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.
Benjamin BillotFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0002-3018-1282
J Eugenio IglesiasFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0001-7569-173X
Satrajit GhoshFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0002-5312-6729
Raquel E GurFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0002-4082-8502
Theodore D SatterthwaiteFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.
David RoalfFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.
Jakob SeidlitzFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0002-8164-7476
Aaron Alexander-BlochFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.ORCID 0000-0001-6554-1893
Lifespan Brain Chart ConsortiumFrom the Lifespan Brain Institute (LiBI) of the Children's Hospital of Philadelphia (CHOP) and Penn Medicine, Philadelphia, Pa (J.M.S., A.O.R., M.G., A.S.M., B.H.C., R.E.G., T.D.S., J.S., A.A.B.); Department of Child and Adolescent Psychiatry and Behavioral Science (J.M.S., J.S., A.A.B.), Department of Radiology (S.S., A.V., S.A., T.P.R., H.H.), PolicyLab and Clinical Futures, CHOP Research Institute (B.H.C.), and Department of Biomedical and Health Informatics (J.E.S., S.S., V.P.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Psychiatry (J.E.S., R.E.G., T.D.S., D.R., J.S., A.A.B.), Department of Radiology (J.E.S., S.S., A.V., S.A., T.P.R., H.H.), Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry (S.C., T.D.S.), and Department of Pediatrics (B.H.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa; Departments of Psychiatry (S.A.B., S.R.W., E.B., R.A.I.B.) and Psychology (R.A.I.B.), University of Cambridge, Cambridge, United Kingdom; Center for Biomedical Image Computation and Analytics (R.T.S.), Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology and Informatics (R.T.S.), and Lifespan Brain Chart Consortium (S.R.W., E.B., R.A.I.B., R.T.S., T.D.S., J.S., A.A.B.), University of Pennsylvania, Philadelphia, Pa; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom (B.B., J.E.I.); Martinos Center for Biomedical Imaging and Department of Radiology (J.E.I.) and Department of Otolaryngology-Head and Neck Surgery (S.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Mass; and McGovern Institute for Brain Research (S.G.) and Computer Science & Artificial Intelligence Laboratory (B.B., J.E.I.), Massachusetts Institute of Technology, Cambridge, Mass.
Funding
Resource DiscoveryP41EB019936 · NIBIB · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI David Nelson Kennedy · 2016 to 2026
$15.2MInter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9MStructural Development of Human Fetal BrainR01MH092535 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI HUANG, HAO · 2011 to 2020
$4.6MHarmonization of Multi-Site Neuroimaging Data from Complex Study DesignsR01MH123550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2020 to 2025
$4.0MUltra-high field GluCEST MRI and MRS in youth at risk for psychosisR01MH120174 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2020 to 2024
$3.8MOlfactory and facial markers of developmental risk for psychosis in 22q11 deletion syndromeR01MH119185 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ROALF, DAVID R · 2019 to 2024
$3.5MReproducible imaging-based brain growth charts for psychiatryR01MH120482 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MILHAM, MICHAEL PETER, SATTERTHWAITE, THEODORE · 2019 to 2023
$3.5MPrecision brain charts for imaging-genomics of schizophrenia and the psychosis spectrumR01MH133843 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI Aaron Felix Alexander-Bloch · 2023 to 2026
$3.2MAdvanced Statistical Analytics of MRI in MSR01NS112274 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2020 to 2024
$2.8MInfant Atlas of Brain PerfusionR01EB031284 · NIBIB · CHILDREN'S HOSP OF PHILADELPHIA · PI HUANG, HAO · 2021 to 2025
$2.4MNobrainer: A robust and validated neural network tool suite for imagersRF1MH121885 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GHOSH, SATRAJIT SUJIT · 2020 to 2020
$2.4MCombined brain and gene network approaches to the developmental hypothesis of schizophreniaK08MH120564 · NIMH · YALE UNIVERSITY · PI ALEXANDER-BLOCH, AARON FELIX · 2019 to 2023
$923kDepartment of HealthMedical Research Council MC_UU_00002/2NIBIB NIH HHS P41 EB019936NIBIB NIH HHS R01 EB031284NIMH NIH HHS K08 MH120564NIMH NIH HHS K08 MH129657NIMH NIH HHS R01 MH092535NIMH NIH HHS R01 MH112847NIMH NIH HHS R01 MH119185NIMH NIH HHS R01 MH120174NIMH NIH HHS R01 MH120482NIMH NIH HHS R01 MH123550NIMH NIH HHS R01 MH125333NIMH NIH HHS R01 MH133843NIMH NIH HHS RF1 MH121885NINDS NIH HHS R01 NS112274
Abstract
Background Clinically acquired brain MRI scans represent a valuable but underused resource for investigating neurodevelopment due to their technical heterogeneity and lack of appropriate controls. These barriers have curtailed retrospective studies of clinical brain MRI scans compared with more costly prospectively acquired research-quality brain MRI scans. Purpose To provide a benchmark for neuroanatomic variability in clinically acquired brain MRI scans with limited imaging pathology (SLIPs) and to evaluate if growth charts from curated clinical MRI scans differed from research-quality MRI scans or were influenced by clinical indication for the scan. Materials and Methods In this secondary analysis of preexisting data, clinical brain MRI SLIPs from an urban pediatric health care system (individuals aged ≤22 years) were scanned across nine 3.0-T MRI scanners. The curation process included manual review of signed radiology reports and automated and manual quality review of images without gross pathology. Global and regional volumetric imaging phenotypes were measured using two image segmentation pipelines, and clinical brain growth charts were quantitatively compared with charts derived from a large set of research controls in the same age range by means of Pearson correlation and age at peak volume. Results The curated clinical data set included 532 patients (277 male; median age, 10 years [IQR, 5-14 years]; age range, 28 days after birth to 22 years) scanned between 2005 and 2020. Clinical brain growth charts were highly correlated with growth charts derived from research data sets (22 studies, 8346 individuals [4947 male]; age range, 152 days after birth to 22 years) in terms of normative developmental trajectories predicted by the models (median
Indexed as
BrainGrowth ChartsChildHeadHumansInfant, NewbornMagnetic Resonance ImagingMaleRetrospective Studies
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