Evidence map›Paper›PMID 37905640›Full record

ArticleIn vivo (Athens, Greece)

UVC-Protective Activity of Lemongrass Among 12 Fat-soluble Herbal Extracts: Rapid Decay Due to Cytotoxicity.

Yusei Otaka, Maki Izawa, Hiroshi Sakagami, Noriyoshi Shiba, Nobutoshi Takahashi, Sei-Ichi Tanuma, Shigeru Amano, Shin Uota, Megumi Inomata, Satoshi Yokose and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Quantification ofIn vivo (Athens, Greece)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yusei OtakaDivision of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan; y-ohtaka@dent.meikai.ac.jp sakagami@dent.meikai.ac.jp.
Maki IzawaDivision of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan.
Hiroshi SakagamiMeikai University Research Institute of Odontology (M-RIO), Saitama, Japan.
Noriyoshi ShibaDivision of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan.
Nobutoshi TakahashiDivision of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan.
Sei-Ichi TanumaMeikai University Research Institute of Odontology (M-RIO), Saitama, Japan.
Shigeru AmanoMeikai University Research Institute of Odontology (M-RIO), Saitama, Japan.
Shin UotaMeikai University Research Institute of Odontology (M-RIO), Saitama, Japan.
Megumi InomataDivision of Microbiology and Immunology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Saitama, Japan.
Satoshi YokoseDivision of Endodontics and Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan.
Katsuyoshi SunagaLaboratory of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Josai University, Saitama, Japan.
Shinichiro HayashiGreen Flask Laboratory, Tokyo, Japan.
Yukari Koga-OgawaFaculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan.
Giichirou NakayaFaculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan.
Shinji KitoDivision of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThe COVID-19 pandemic led to the rapid spread of the use of ultraviolet C (UVC) sterilizers in many public facilities. Considering the harmful effects of prolonged exposure to UVC, manufacturing of safe skin care products is an important countermeasure. In continuation of our recent study of water-soluble herbal extracts, the present study aimed at searching for anti-UVC components from fat-soluble herbal extracts. MATERIALS AND

methodsHuman dermal fibroblast and melanoma cells were exposed to UVC (1.193 W/m

resultsOnly lemongrass extract, among 12 fat-soluble herbal extracts, showed significant anti-UVC activity, comparable to that of lignified materials and tannins, but exceeding that of N-acetyl-L-cysteine and resveratrol. Lemongrass extract was highly cytotoxic, producing a subG

conclusionRemoval of cytotoxic principle(s) from lemongrass extract is crucial to producing long-lasting UVC-protective effects.

Indexed as

CymbopogonPlant ExtractsHumansPandemicsSkinUltraviolet RaysPlant Extractsdermal fibroblastmalignancymelanomaprotectionUVC sensitivitywater-soluble herbal extract

Identifiers

PMID37905640
PMCPMC10621405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.