Evidence map›Paper›PMID 37905617›Full record

ArticleIn vivo (Athens, Greece)

Chemical Carcinogen (Dimethyl-benzanthracene) Induced Transplantable Cancer in Fanconi Anemia (Fanca-/-) Mice.

Michael W Epperly, Amitava Mukherjee, Renee Fisher, Donna Shields, Wen Hou, Hong Wang, Lora H Rigatti, Anthony Green, M Saiful Huq, Joel S Greenberger

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Michael W EpperlyDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, U.S.A.
Amitava MukherjeeDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, U.S.A.
Renee FisherDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, U.S.A.
Donna ShieldsDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, U.S.A.
Wen HouDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, U.S.A.
Hong WangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA, U.S.A.
Lora H RigattiD.L.A.R. - Veterinary Services, University of Pittsburgh, Pittsburgh, PA, U.S.A.
Anthony GreenDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, U.S.A.
M Saiful HuqDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, U.S.A.
Joel S GreenbergerDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, U.S.A.; greenbergerjs@upmc.edu.
University of Pittsburgh · US

Funding

LR-IL-22 for Mitigation and Management of Radiation InjuriesU01AI172885 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOEL S GREENBERGER · 2023 to 2026
$2.4M
NIAID NIH HHS U01 AI172885
6 · The paper itself

Abstract

BACKGROUND/

aimPatients with radiation sensitive Fanconi anemia (FA) are presenting with cancers of the oral cavity, oropharynx, and other anatomic locations. MATERIALS AND

methodsAnimal models for cancer in FA mice used orthotopic tumors from wild type mice. We derived a cancer cell line from Fanca-/- mice by topical application of the chemical carcinogen dimethyl benzanthracene (DMBA).

resultsA Fanca-/- mouse rhabdomyosarcoma was derived from a Fanca-/- (129/Sv) mouse. The in vitro clonogenic survival of the Fanca-/- clone 6 cancer cell line was consistent with the FA genotype. Transplanted tumors demonstrated hypoxic centers surrounded by senescent cells.

conclusionThis Fanca-/- mouse syngeneic cancer should provide a valuable resource for discovery and development of new normal tissue radioprotectors for patients with FA and cancer.

Indexed as

Fanconi AnemiaNeoplasmsAnimalsBenz(a)AnthracenesCarcinogensCell LineFanconi Anemia Complementation Group A ProteinHumansMicebenz(a)anthraceneBenz(a)AnthracenesCarcinogensFanca protein, mouseFanconi Anemia Complementation Group A ProteincarcinogenFanconi anemiatransplantable tumor

Identifiers

PMID37905617
PMCPMC10621406
OpenAlexW4388035495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.