Evidence map›Paper›PMID 37905615›Full record

ArticleIn vivo (Athens, Greece)

Heart and Coronary Artery Dose Sparing in Left-sided Breast Cancer: 3D-Conformal Radiotherapy

Isabella Palumbo, Marta Marcantonini, Michele Scialpi, Vittorio Bini, Maika DI Benedetto, Serena Nucciarelli, Christian Fulcheri, Elisabetta Perrucci, Cynthia Aristei

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Isabella Palumbo *Radiation Oncology Section, University of Perugia and Perugia General Hospital, Perugia, Italy; isabella.palumbo@unipg.it.
Marta Marcantonini *Medical Physics Unit, Perugia General Hospital, Perugia, Italy.
Michele ScialpiDiagnostic Imaging Division, University of Perugia and Perugia General Hospital, Perugia, Italy.
Vittorio BiniInternal Medicine Endocrine and Metabolic Science Section, University of Perugia, Perugia, Italy.
Maika DI BenedettoRadiation Oncology Section, University of Perugia, Perugia, Italy.
Serena NucciarelliRadiation Oncology Section, University of Perugia, Perugia, Italy.
Christian FulcheriMedical Physics Unit, Perugia General Hospital, Perugia, Italy.
Elisabetta PerrucciRadiation Oncology Division, Perugia General Hospital, Perugia, Italy.
Cynthia AristeiRadiation Oncology Section, University of Perugia and Perugia General Hospital, Perugia, Italy.
University of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimTo compare heart, left ventricle (LV) and coronary artery dose-sparing with three-dimensional conformal radiotherapy (3D-CRT) vs. helical tomotherapy (HT) in left-sided breast cancer (BC). PATIENTS AND

methods3D-CRT and HT treatments were planned for 20 patients (pts). Computed tomography (CT) scans without and with intravenous contrast (ic) were performed and co-registered. Left breast and organs at risk (OARs) were contoured. Dose-volume histograms (DVHs) for 3D-CRT and HT treatment plans were evaluated in terms of planning target volume for evaluation (PTVeval) coverage and dose to the OARs.

resultsHT provided the best target coverage and significantly reduced D2% and mean dose to the left anterior descending artery (LADA) and to the LADA-planning organ at risk volume (PRV), D2%, V5 and mean dose to the LV and D2% and V25 to the heart. As expected, due to the rotational delivery, the dose to all other coronary arteries and their PRV, contralateral breast and lungs was higher with HT.

conclusionIn left-sided BC, HT provided the best target coverage and significantly reduced LV and LADA doses. Moreover D2% and V25 to the heart were significantly reduced. Further studies are needed to correlate dosimetric findings with in-depth cardiac monitoring.

Indexed as

Breast NeoplasmsRadiotherapy, ConformalRadiotherapy, Intensity-ModulatedUnilateral Breast NeoplasmsCoronary VesselsFemaleHeartHumansRadiotherapy DosageRadiotherapy Planning, Computer-Assistedcoronary arterieshearthelical tomotherapyLeft-sided breast cancerleft ventriclethree-dimensional conformal radiotherapy

Identifiers

PMID37905615
PMCPMC10621428
OpenAlexW4388034993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.