Evidence map›Paper›PMID 37905217›Full record

ArticleMagnetic resonance (Gottingen, Germany)2021

High-affinity tamoxifen analogues retain extensive positional disorder when bound to calmodulin.

Lilia Milanesi, Clare R Trevitt, Brian Whitehead, Andrea M Hounslow, Salvador Tomas, Laszlo L P Hosszu, Christopher A Hunter, Jonathan P Waltho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance (Gottingen, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Lilia MilanesiDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.
Clare R TrevittDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.
Brian WhiteheadDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.
Andrea M HounslowDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.
Salvador TomasDepartment of Biological Sciences, School of Science, Birkbeck University of London, London WC1E 7HX, UK.
Laszlo L P HosszuDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.
Christopher A HunterDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Jonathan P WalthoDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.
University of Sheffield · GBDemos · USMRC Prion Unit · GBUniversity of Cambridge · GBUniversity of Manchester · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Using a combination of NMR and fluorescence measurements, we have investigated the structure and dynamics of the complexes formed between calcium-loaded calmodulin (CaM) and the potent breast cancer inhibitor idoxifene, a derivative of tamoxifen. High-affinity binding (

Identifiers

PMID37905217
PMCPMC10539762
OpenAlexW3128667786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.