Evidence map›Paper›PMID 37905131›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Probing Human Heart TCA Cycle Metabolism and Response to Glucose Load using Hyperpolarized [2-

Hsin-Yu Chen, Jeremy W Gordon, Nicholas Dwork, Brian T Chung, Andrew Riselli, Sanjay Sivalokanathan, Robert A Bok, James B Slater, Daniel B Vigneron, M Roselle Abraham and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Hsin-Yu ChenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, United States.
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, United States.
Nicholas DworkDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, United States.
Brian T ChungDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, United States.
Andrew RiselliSchool of Pharmacy, University of California, San Francisco, United States.
Sanjay SivalokanathanDivision of Cardiology, University of California, San Francisco, United States.
Robert A BokDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, United States.
James B SlaterDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, United States.
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, United States.
M Roselle AbrahamDivision of Cardiology, University of California, San Francisco, United States.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, United States.
University of California, San Francisco · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Hyperpolarized Carbon-13 Metabolic MRI of the Human HeartR33HL161816 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABRAHAM, MARIA ROSELLE, LARSON, PEDER ERIC ZUFALL · 2022 to 2023
$965k
NHLBI NIH HHS R33 HL161816NIBIB NIH HHS P41 EB013598
6 · The paper itself

Abstract

Introduction: The normal heart has remarkable metabolic flexibility that permits rapid switching between mitochondrial glucose oxidation and fatty acid (FA) oxidation to generate ATP. Loss of metabolic flexibility has been implicated in the genesis of contractile dysfunction seen in cardiomyopathy. Metabolic flexibility has been imaged in experimental models, using hyperpolarized (HP) [2- Methods: Good Manufacturing Practice [2- Results: The study protocol which included HP substrate injection, MR scanning and oral glucose load, was performed safely without adverse events. Key downstream metabolites of [2- Conclusions: HP [2-

Indexed as

Hyperpolarized 13C MR SpectroscopyMetabolismOral Glucose Load TestPyruvateTCA Cycle

Identifiers

PMID37905131
PMCPMC10615004
OpenAlexW4387771931

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.