Evidence map›Paper›PMID 37905117›Full record

ArticlebioRxiv : the preprint server for biology2023

NODDI-derived measures of microstructural integrity in medial temporal lobe white matter pathways are associated with Alzheimer's disease pathology and cognitive outcomes.

Dana M Parker, Jenna N Adams, Soyun Kim, Liv McMillan, Michael A Yassa, Alzheimer’s Disease Neuroimaging Initiative

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dana M ParkerDepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory, University of California, Irvine.
Jenna N AdamsDepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory, University of California, Irvine.
Soyun KimDepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory, University of California, Irvine.
Liv McMillanDepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory, University of California, Irvine.
Michael A YassaDepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory, University of California, Irvine.
Alzheimer’s Disease Neuroimaging Initiative
University of California, Irvine · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Neuroimaging biomarkers for cognitive decline in elderly with amyloid pathologyR01AG053555 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Michael A Yassa · 2017 to 2026
$17.0M
Testing the role of tau pathology in disrupting hippocampal CA1 memory function in older adults at risk for Alzheimer’s diseaseR21AG075464 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI YASSA, MICHAEL A · 2022 to 2023
$432k
Effect of hippocampal tau pathology on CA1 function and memory processing in agingF32AG074621 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI ADAMS, JENNA NICOLE · 2021 to 2023
$202k
NIA NIH HHS F32 AG074621NIA NIH HHS R01 AG053555NIA NIH HHS R21 AG075464NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

introductionDiffusion tensor imaging has been used to assess white matter (WM) changes in the early stages of Alzheimer's disease (AD). However, the tensor model is necessarily limited by its assumptions. Neurite Orientation Dispersion and Density Imaging (NODDI) can offer insights into microstructural features of WM change. We assessed whether NODDI more sensitively detects AD-related changes in medial temporal lobe WM than traditional tensor metrics.

methodsStandard diffusion and NODDI metrics were calculated for medial temporal WM tracts from 199 older adults drawn from ADNI3 who also received PET to measure pathology and neuropsychological testing.

resultsNODDI measures in medial temporal tracts were more strongly correlated to cognitive performance and pathology than standard measures. The combination of NODDI and standard metrics exhibited the strongest prediction of cognitive performance in random forest analyses.

conclusionsNODDI metrics offer additional insights into contributions of WM degeneration to cognitive outcomes in the aging brain.

Indexed as

agingAlzheimer’s diseaseamyloid-betadiffusion tensor imagingmemoryNeurite Orientation Dispersion and Density Imagingtauwhite matter

Identifiers

PMID37905117
PMCPMC10614746
OpenAlexW4387665738

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.