Evidence map›Paper›PMID 37905116›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival.

Linda Kachuri, Geno A Guerra, George A Wendt, Helen M Hansen, Annette M Molinaro, Paige Bracci, Lucie McCoy, Terri Rice, John K Wiencke, Jeanette E Eckel-Passow and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Linda KachuriDepartment of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA.
Geno A GuerraDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
George A WendtDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
Helen M HansenDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
Annette M MolinaroDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
Paige BracciDepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA.
Lucie McCoyDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
Terri RiceDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
John K WienckeDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
Jeanette E Eckel-PassowDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.
Robert B JenkinsDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Margaret WrenschDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
Stephen S FrancisDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA.
University of California, San Francisco · USMayo Clinic · USStanford University · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
Targeted MV-CEA as a Potent Antitumor Agent against GBMP50CA108961 · NCI · MAYO CLINIC ROCHESTER · PI O'NEILL, BRIAN PATRICK · 2004 to 2015
$22.5M
GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5M
International Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Training in Molecular& Genetic Epidemiology of CancerR25CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2005 to 2018
$6.5M
Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic DataR01AI128775 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JILL Allison HOLLENBACH, STEVEN JOHN MACK · 2017 to 2026
$4.5M
UNDERSTANDING THE INTERACTIONS BETWEEN GERMLINE AND SOMATIC ALTERATIONS in the PATHOGENESIS OF GLIOMASR01CA230712 · NCI · MAYO CLINIC ROCHESTER · PI JENKINS, ROBERT B. · 2018 to 2022
$3.3M
Discovering Infection-mediated Pathways of Glioma Etiology and Prognosis by Leveraging Multiplex Serology and ImmunogenomicsR01CA266676 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRANCIS, STEPHEN STARKO · 2022 to 2025
$2.6M
Biomarkers of survival in glioma epidemiologyR01CA126831 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 2008 to 2013
$2.5M
Comprehensive Investigation of Multiple Myeloma Genetic Susceptibility in African AmericansR00CA246076 · NCI · STANFORD UNIVERSITY · PI KACHURI, MIRLINDA · 2022 to 2024
$747k
NCCDPHP CDC HHS NU58DP006344NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032INCI NIH HHS P50 CA097257NCI NIH HHS P50 CA108961NCI NIH HHS R00 CA246076NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA126831NCI NIH HHS R01 CA139020NCI NIH HHS R01 CA230712NCI NIH HHS R01 CA266676NCI NIH HHS R25 CA112355NCI NIH HHS T32 CA151022NCRR NIH HHS UL1 RR024131NIAID NIH HHS R01 AI128775
6 · The paper itself

Abstract

Glioma is a highly fatal brain tumor comprised of molecular subtypes with distinct clinical trajectories. Observational studies have suggested that variability in immune response may play a role in glioma etiology. However, their findings have been inconsistent and susceptible to reverse causation due to treatment effects and the immunosuppressive nature of glioma. We applied genetic variants associated (p<5×10

Identifiers

PMID37905116
PMCPMC10614986
OpenAlexW4387665780

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.