Evidence map›Paper›PMID 37905108›Full record

ArticlebioRxiv : the preprint server for biology2023

Nanomechanics of wild-type and mutant dimers of the tip-link protein protocadherin 15.

Camila M Villasante, Xinyue Deng, Joel E Cohen, A J Hudspeth

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Camila M VillasanteLaboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065 USA.
Xinyue DengLaboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065 USA.
Joel E CohenLaboratory of Populations, The Rockefeller University, New York, NY 10065 USA.
A J HudspethLaboratory of Sensory Neuroscience, The Rockefeller University, New York, NY 10065 USA.
Rockefeller University · USEarth Island Institute · USHoward Hughes Medical Institute · US

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Protocadherin 15 as a critical component of the gating spring of human hearingF30DC020104 · NIDCD · WEILL MEDICAL COLL OF CORNELL UNIV · PI VILLASANTE, CAMILA MARIE · 2021 to 2024
$201k
NIDCD NIH HHS F30 DC020104NIGMS NIH HHS T32 GM007739
6 · The paper itself

Abstract

Mechanical force controls the opening and closing of mechanosensitive ion channels atop the hair bundles of the inner ear. The filamentous tip link connecting transduction channels to the tallest neighboring stereocilium modulates the force transmitted to the channels and thus changes their probability of opening. Each tip link comprises four molecules: a dimer of protocadherin 15 and a dimer of cadherin 23, all of which are stabilized by Ca

Identifiers

PMID37905108
PMCPMC10614884
OpenAlexW4387771321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.