Evidence map›Paper›PMID 37905106›Full record

ArticlebioRxiv : the preprint server for biology2023

Parkinson's-linked LRRK2-G2019S derails AMPAR trafficking, mobility and composition in striatum with cell-type and subunit specificity.

Swati Gupta, Christopher A Guevara, Alexander Tielemans, George W Huntley, Deanna L Benson

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Swati GuptaORCID 0000-0003-1558-0469
Christopher A Guevara
Alexander Tielemans
George W HuntleyORCID 0000-0003-3645-6192
Deanna L BensonORCID 0000-0001-7037-1147
Allen Institute for Brain Science · US

Funding

Training Program in NeuroscienceT32MH087004 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GEORGE W. HUNTLEY · 2009 to 2026
$4.0M
Impact of human disease-causing mutation on striatal synaptic and behavioral plasticityR01NS107512 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L, HUNTLEY, GEORGE W. · 2019 to 2022
$2.1M
Building Synaptic CytoskeletonR01NS115469 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L · 2020 to 2023
$1.8M
Leica TCS SP8 STED3XS10OD021838 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L · 2017 to 2017
$1.2M
A Model for Homeostatic Plasticity in StriatumR21NS130841 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BENSON, DEANNA L, HUNTLEY, GEORGE W. · 2023 to 2023
$465k
NIH HHS S10 OD021838NIMH NIH HHS T32 MH087004NINDS NIH HHS R01 NS107512NINDS NIH HHS R01 NS115469NINDS NIH HHS R21 NS130841
6 · The paper itself

Abstract

Parkinson's (PD) is a multi-factorial disease that affects multiple brain systems and circuits. While defined by motor symptoms caused by degeneration of brainstem dopamine neurons, debilitating non-motor abnormalities in fronto-striatal based cognitive function are common, appear early and are initially independent of dopamine. Young adult mice expressing the PD-associated G2019S missense mutation in SIGNIFICANCE STATEMENT: Mutations in LRRK2 are common genetic risks for PD.

Identifiers

PMID37905106
PMCPMC10614818
OpenAlexW4387707689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.