Evidence map›Paper›PMID 37905081›Full record

ArticlebioRxiv : the preprint server for biology2023

Lipids with negative spontaneous curvature decrease the solubility of the cancer drug paclitaxel in liposomes.

Victoria Steffes, Scott MacDonald, John Crowe, Meena Murali, Kai K Ewert, Youli Li, Cyrus R Safinya

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Victoria SteffesMaterials Department, University of California, Santa Barbara, California 93106, USA.
Scott MacDonaldMaterials Research Laboratory, University of California, Santa Barbara, California 93106, USA.
John CroweMaterials Research Laboratory, University of California, Santa Barbara, California 93106, USA.
Meena MuraliMaterials Department, University of California, Santa Barbara, California 93106, USA.
Kai K EwertMaterials Department, University of California, Santa Barbara, California 93106, USA.
Youli LiPhysics Department, University of California, Santa Barbara, California 93106, USA.
Cyrus R SafinyaMaterials Department, University of California, Santa Barbara, California 93106, USA.
University of California, Santa Barbara · US

Funding

Functionalized Lipid Carriers for Nucleic-Acid and Drug TherapeuticsR01GM130769 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SAFINYA, CYRUS R · 2018 to 2021
$1.4M
NIGMS NIH HHS R01 GM130769
6 · The paper itself

Abstract

Paclitaxel (PTX) is a hydrophobic small-molecule cancer drug that loads into the membrane (tail) region of lipid carriers such as liposomes and micelles. The development of improved lipid-based carriers of PTX is an important objective to generate chemotherapeutics with fewer side effects. The lipids 1,2-dioleoyl-

Identifiers

PMID37905081
PMCPMC10614943
OpenAlexW4387845586

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.