Evidence map›Paper›PMID 37905068›Full record

ArticlebioRxiv : the preprint server for biology2023

Genetic deficiency of ribosomal rescue factor HBS1L causes retinal dystrophy associated with Pelota and EDF1 depletion.

Shiyu Luo, Bilal Alwattar, Qifei Li, Kiran Bora, Alexandra K Blomfield, Jasmine Lin, Anne Fulton, Jing Chen, Pankaj B Agrawal

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Shiyu LuoDivision of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine and Holtz Children's Hospital, Jackson Health System, Miami, FL 33136, USA.
Bilal AlwattarDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School; Boston, MA 02115, USA.
Qifei LiDivision of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine and Holtz Children's Hospital, Jackson Health System, Miami, FL 33136, USA.
Kiran BoraDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School; Boston, MA 02115, USA.
Alexandra K BlomfieldDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School; Boston, MA 02115, USA.
Jasmine LinDivision of Genetics and Genomics and The Manton Center for Orphan Disease Research, Boston, MA 02115, USA.
Anne FultonDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School; Boston, MA 02115, USA.
Jing ChenDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School; Boston, MA 02115, USA.
Pankaj B AgrawalDivision of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine and Holtz Children's Hospital, Jackson Health System, Miami, FL 33136, USA.
Boston Children's Hospital · US

Funding

RORalpha mediates chronic subretinal inflammation associated with AMDR01EY024963 · NEI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, JING · 2015 to 2025
$4.2M
Regulation of RPE degeneration by REV-ERBalphaR01EY031765 · NEI · BOSTON CHILDREN'S HOSPITAL · PI JING CHEN · 2020 to 2026
$2.7M
Wnt signaling-mediated control of blood-retinal barrierR01EY028100 · NEI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, JING · 2017 to 2021
$2.2M
NEI NIH HHS R01 EY024963NEI NIH HHS R01 EY028100NEI NIH HHS R01 EY031765Wellcome Trust
6 · The paper itself

Abstract

Inherited retinal diseases (IRDs) encompass a genetically diverse group of conditions in which mutations in genes critical to retinal function lead to progressive loss of photoreceptor cells and subsequent visual impairment. A handful of ribosome-associated genes have been implicated in retinal disorders alongside neurological phenotypes. This study focuses on the

Identifiers

PMID37905068
PMCPMC10614867
OpenAlexW4387823590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.